24251-93-2Relevant articles and documents
Immobilization of components in polymer membrane-based calcium-selective bulk optodes
Rosatzin, Thomas,Holy, Petr,Seiler, Kurt,Rusterholz, Bruno,Simon, Wilhelm
, p. 2029 - 2035 (1992)
A large variety of optical sensors based on thin plasticized PVC membranes have been realized in the past. The organic membrane (bulk optode) contains the analyte recognition molecule such as a selective neutral ionophore, a H+-selective chromoionophore, and Ilpophllic anionic sites. In order to improve the lifetime of analytically relevant sensing layers, their active components are covaiently immobilized to the polymeric matrix. Different Ca2+-selective bulk optodes with mobile or fixed chromolonophores and anionic sites are characterized and discussed with respect to sensor behavior such as dynamic range, repeatability, response time, selectivity, and lifetime. In general, the response time increases upon immobilization of components owing to limited diffusion within the membrane phase, whereas the lifetime is enhanced drastically by a hindered loss of membrane components into the sample.
Diaryldiazepine Prodrugs for the Treatment of Neurological and Psychological Disorders
-
Page/Page column 68, (2011/07/29)
The present invention provides prodrug compounds of diaryldiazepine drug compounds.
3,4-Alkylenedioxypyrroles: Functionalized derivatives as monomers for new electron-rich conducting and electroactive polymers
Zong,Reynolds
, p. 6873 - 6882 (2007/10/03)
New functionalized derivatives of 3,4-ethylenedioxypyrrole (EDOP, 5a) and 3,4-(1,3-propylenedioxy) pyrrole (ProDOP, 5b) as especially electron-rich monomers which yield highly electroactive and stable conducting polymers useful for a diverse set of applications have been synthesized. N-Alkylations of ProDOP were carried out to yield a variety of ProDOP derivatives having alkyl, sulfonatoalkoxy, glyme, and glyme alcohol pendant chains. Iodization of EDOP and ProDOP via iodo-decarboxylation afforded iodo-functionalized derivatives useful for subsequent aryl coupling chemistry. N-Protection and formylation of EDOP, followed by Knoevenagel condensation of the resultant 2-formyl-EDOP with aryl acetonitrile derivatives, led to 1-cyano-2-(2-(3,4-ethylenedioxypyrryl))-1-(2-thienyl)vinylene (23) (Th-CNV-EDOP) and 1-cyano-2-(2-(3,4-ethylenedioxypyrryl))-1-(2-(3,4-ethylenedioxythienyl) vinylene (26) (EDOT-CNV-EDOP). A 14-crown-4-ether 34 based dioxypyrrole was synthesized with a cavity potentially useful for lithium ion coordination and sensing in the resultant electroactive polymer. C-Alkylated ProDOPs (43a, 43b, and 43c) containing octyl, ethylhexyl, and dioctyl substituents appended to the central methylene of the propylene bridge, were prepared as monomers for potentially soluble π-conjugated polymers.