24253-16-5

Usage

Functional groups

Ketone, Chlorine atom, 3-Methoxyphenyl group

Chemical structure

A ketone with a chlorine atom attached to the first carbon, a 3-methoxyphenyl group attached to the third carbon, and a carbonyl group (C=O) at the second carbon.

Organic synthesis

Used as a building block for the synthesis of various pharmaceuticals and bioactive compounds.

Medicinal chemistry

Employed in the development of new drugs and therapeutic agents.

Reagent

Utilized in chemical reactions to facilitate specific transformations.

Precursor

Serves as a starting material for the preparation of other organic compounds.

Antimicrobial

Exhibits properties that can inhibit the growth of microorganisms.

Anti-inflammatory

Demonstrates the ability to reduce inflammation in biological systems.

Solubility

Generally soluble in organic solvents such as ethanol, methanol, and acetone, but may have limited solubility in water.

Stability

Relatively stable under normal conditions, but sensitive to heat, light, and strong bases or acids.

Safety precautions

Handle with care, as it may be toxic or harmful if ingested, inhaled, or absorbed through the skin. Use appropriate personal protective equipment (PPE) and follow proper disposal procedures.

Upstream product

• 186581-53-3 diazomethane 
• 6834-42-0 3-methoxyphenylacetic acid chloride 
• 67442-07-3 2-chloro-N-methoxy-N-methylacetamide 
• 1798-09-0 m-methoxyphenylacetic acid 

Downstream Products

• 1114770-68-1 C₂₀H₂₇N₃O₃S 
• 1114770-51-2 1-((4-(3-methoxybenzyl)thiazol-2-yl)methyl)-4-(4-methoxyphenylsulfonyl)piperazine 
• 1114770-50-1 4-(3-methoxybenzyl)-2-(1-(4-methoxyphenylsulfonyl)piperidin-4-yl)thiazole 
• 100705-25-7 1-chloro-3-(3-methoxy-phenyl)-propan-2-ol 

Relevant academic research and scientific papers

One-step synthesis of 1-chloro-3-arylacetone derivatives from arylacetic acids

A practical one-step method has been developed to prepare α-chloroketones from readily available, inexpensive phenylacetic acid derivatives. The method utilizes the unique reactivity of an intermediate Mg.enolate dianion, which displays selectivity for the carbonyl carbon of chloromethyl carbonyl electrophiles. Decarboxylation of the intermediate occurs spontaneously during the reaction quench. The utility of the reaction products has been demonstrated through the total synthesis of the natural product cimiracemate B.

N-SULFONYL THIAZOLYLPIPERAZINE DERIVATIVES AND RELATED N-SULFONYL HETEROCYCLIC DERIVATIVES FOR THE TREATMENT OF NEURO DEGENERATIVE DISEASES

This invention provides thiazolylpiperazine derivatives, and N-sulfonyl heterocyclic derivatives including phenyl- and benzyl-thiazolylpiperidine derivatives, and pharmaceutically acceptable salts thereof, which are useful active ingredients for administration in a method for the treatment of an α-synucleopathy such as Parkinson's disease, diffuse Lewy body disease, traumatic brain injury, amyotrophic lateral sclerosis, Niemann-Pick disease, Hallervorden-Spatz syndrome, Down syndrome, neuroaxonal dystrophy, multiple system atrophy and Alzheimer's disease. This invention also provides methods for making such derivatives, and pharmaceutical compositions including such derivatives together with pharmaceutically acceptable excipients.