24254-61-3Relevant articles and documents
Pyrimidinedione derivatives and antiarrythmic agents containing the same
-
, (2008/06/13)
A pyrimidinedione derivative compound has a basic backbone in which a phenyl group part and a pyrimidinedione part are linked by a linking structure comprising an alkyl chain containing two nitrogen atoms. This linking structure is represented by STR1 [wherein A is --(CH2)n --, --CO-- or --O--(CH2)m --; each of R1 and R2 is independently a hydrogen atom or a lower alkyl group which may be substituted by a hydroxyl group, or R1 and R2 may be so linked with each other as to make an alkylene chain and thus form a heterocyclic structure; R5 is a halogen atom, a hydroxyl group, a lower alkyloxycarbonyl group, a lower alkyloxy group which may be substituted by a lower alkyloxy group, or a lower alkyl group which may be substituted by a hydroxyl group, or R5 may be so linked with R1 as to make an alkylene chain and thus form a heterocyclic structure; n is 0, 1, 2 or 3 (when R5 is the hydroxyl group, n≠0); m is 0, 1, 2 or 3; and k is 0, 1, 2 or 3 (however, a compound in which A is --O--(CH2)m -- and R5 is the hydroxyl group is excluded from the pyrimidinedione derivative)]. The pyrimidinedione derivative and its acid addition salt are useful for a medical treatment of cardiac arrhythmias.