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1-(4-Benzyl-3,4-dihydroquinoxalin-1(2H)-yl)ethanone is a complex organic compound with the molecular formula C17H17NO. It is a derivative of quinoxaline, a heterocyclic aromatic organic compound consisting of a benzene ring fused to a diazine ring. The compound features a 3,4-dihydroquinoxalin-1(2H)-yl group, which is a reduced form of quinoxaline, attached to a 4-benzyl substituent. The molecule also contains an ethanone group, which is a two-carbon ketone functional group. This chemical is known for its potential applications in pharmaceuticals and medicinal chemistry, particularly in the development of drugs targeting the central nervous system. Its structure and properties make it a subject of interest for researchers exploring novel therapeutic agents.

2427-93-2

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2427-93-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 2427-93-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,4,2 and 7 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 2427-93:
(6*2)+(5*4)+(4*2)+(3*7)+(2*9)+(1*3)=82
82 % 10 = 2
So 2427-93-2 is a valid CAS Registry Number.

2427-93-2Downstream Products

2427-93-2Relevant academic research and scientific papers

Discovery of Tetrahydroquinoxalines as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the Second Bromodomain

Law, Robert P.,Atkinson, Stephen J.,Bamborough, Paul,Chung, Chun-Wa,Demont, Emmanuel H.,Gordon, Laurie J.,Lindon, Matthew,Prinjha, Rab K.,Watson, Allan J. B.,Hirst, David J.

, p. 4317 - 4334 (2018)

The bromodomain and extra-terminal domain (BET) family of proteins bind acetylated lysine residues on histone proteins. The four BET bromodomains - BRD2, BRD3, BRD4, and BRDT - each contain two bromodomain modules. BET bromodomain inhibition is a potential therapy for various cancers and immunoinflammatory diseases, but few reported inhibitors show selectivity within the BET family. Inhibitors with selectivity for the first or second bromodomain are desired to aid investigation of the biological function of these domains. Focused library screening identified a series of tetrahydroquinoxalines with selectivity for the second bromodomains of the BET family (BD2). Structure-guided optimization of the template improved potency, selectivity, and physicochemical properties, culminating in potent BET inhibitors with BD2 selectivity.

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