243117-90-0

Upstream product

• 243117-88-6 2-(7-methoxy-5,8-dimethyl-2-oxo-2,3,4,5-tetrahydro-benzo[b]oxepin-5-yl)-2-methyl-propionic acid methyl ester 
• 868156-99-4 2-allyl-2-(2,5-dimethoxy-4-methyl-phenyl)-3,3-dimethyl-pent-4-enoic acid methyl ester 
• 868157-03-3 1-(2,5-dimethoxy-4-methyl-phenyl)-2,2-dimethyl-cyclopent-3-enecarboxylic acid methyl ester 
• 878774-45-9 [1-(2,5-dimethoxy-4-methyl-phenyl)-2,2-dimethyl-cyclopent-3-enyl]-methanol 
• 878774-36-8 1-(2,5-dimethoxy-4-methyl-phenyl)-2,2-dimethyl-cyclopent-3-enecarbaldehyde 
• 878774-22-2 3,3,4-trimethyl-4-(2,5-dimethoxy-4-methylphenyl)cyclopentene 
• 878774-38-0 3-(2,5-dimethoxy-4-methyl-phenyl)-2,2,3-trimethyl-cyclopentanol 
• 678149-59-2 4-(2,5-dimethoxy-4-methylphenyl)-4,5,5-trimethyl-cyclopent-2-enone 

Downstream Products

• 28917-12-6 (+/-)-cuparene-1,,4-quinone 
• 864934-77-0 4-methoxy-5-methyl-2-(1,2,2-trimethylcyclopentyl)phenol 
• 243462-89-7 1-(2,5-dimethoxy-4-methylphenyl)-1,2,2-trimethyl-cyclopentane 

Relevant academic research and scientific papers

Total synthesis of enokipodins A-D and cuparene-1 ,4-diol

A Claisen rearrangement and RCM reaction based sequence has been developed for total synthesis of the antifungal sesquiterpenes enokipodins A-D and cuparene-1 ,4-diol starting from 2,5-dimethoxy-4-methythydroquinone. Copyright

Palladium (II) catalyzed 5-endo epoxynitrile cyclizations: total syntheses of enokipodins A and B

New total syntheses of the cuparenic sesquiterpenes enokipodins A and B were accomplished. The key step involves a novel, cationic-controlled and palladium (II) improved, 5-endo cyclization of an α-aryl-δ-epoxynitrile. The cyclization occurs with unmatched regioselectivity and high stereoselectivity. The synthesis is completed in 5 steps achieving yields of 50% for enokipodin A and 55% for enokipodin B.

Convenient formal synthesis of (±)-cuparene, (±)-enokipodins A and B, and (±)-cuparene-1,4-quinone

A Bronsted or Lewis acid mediated semi-pinacolic rear-rangement effected on the diastereomers of cyclobutanol derivatives leads efficiently to useful intermediates in the synthesis of cuparene-type sesquiterpenes. The cyclobutanols are themselves easily o

The first total synthesis of (±)-lagopodin A

The first total synthesis of (±)-lagopodin A and a formal total synthesis of enokipodins A and B is described. The requisite precursors containing two vicinal quaternary carbon atoms were assembled employing Claisen rearrangement and an RCM reaction as ke

The First Total Synthesis of the Antimicrobial Sesquiterpenes (±)-Enokipodins A and B

Efficient first total synthesis of antimicrobial sesquiterpenes enokipodins A and B (1 and 2, respectively) and formal total synthesis of cuparene-1,4-diol (5) and cuparene-1,4-quinone (7) have been accomplished starting from 2,5-dimethoxy-4-methyl-acetop

Facile total synthesis of (±)-α-herbertenol, (±)-1,4-cuparenediol and (±)-cuparene-1,4-quinone

The total syntheses of the bicyclic sesquiterpene phenols (±)-α-herbertenol (1) and (±)-1,4-cuparenediol (2) have been successfully accomplished involving copper-catalysed conjugate addition of Grignard reagents to unsaturated dinitriles and α,α-dimethyla

Facile total synthesis of (±)-α-herbertenol, (±)-α-cuparenone and (±)-HM-1 methyl ether involving alkylation of hindered esters

The total syntheses of (±)-α-herbertenol 1, (±)-α-cuparenone 4 and (±)-HM-1 methyl ether 3 have been successfully accomplished involving α,α- dimethylation of the esters 8a, 17 and 8b respectively as key steps.