243125-06-6Relevant academic research and scientific papers
Structure-based design, synthesis and antitumoral evaluation of enulosides
Santos, Jonh A.M.,Santos, Cosme S.,Almeida, Claudia L.A.,Silva, Thiago D.S.,Freitas Filho, Jo?o R.,Milit?o, Gardenia C.G.,da Silva, Teresinha G.,da Cruz, Carlos H.B.,Freitas, Juliano C.R.,Menezes, Paulo H.
, p. 192 - 201 (2017/02/15)
Enulosides, carbohydrate derivatives containing an α,β-unsaturated carbonyl unit, were designed and obtained in high yields and isomeric purity. All synthesized compounds exhibited antitumoral activity in micromolar range against four tested tumor cells lines, being the best results observed for HL-60?cells. These compounds open new possibilities to prepare an array of more active, site-specific or selective antitumor agents. 2016 Elsevier Ltd. All rights reserved.
Stereocontrolled palladium(0)-catalyzed preparation of unsaturated azidosugars: An easy access to 2- and 4-aminoglycosides
De Oliveira, Ronaldo N.,Cottier, Louis,Sinou, Denis,Srivastava, Rajendra M.
, p. 8271 - 8281 (2007/10/03)
The palladium-catalyzed substitution of alkyl 4,6-di-O-acetyl-α-d- erythro-hex-2-eno-pyranosides using NaN3 as the nucleophile gave predominantly the corresponding alkyl 2-azido-2,3,4-trideoxy-α-d-threo- hex-2-enopyranosides in the presence of
Synthesis of new branched-chain amino sugars
De Freitas Filho, Joao R.,Srivastava, Rajendra M.,Da Silva, Waldenberg J.P.,Cottier, Louis,Sinou, Denis
, p. 673 - 680 (2007/10/03)
1,3-Dipolar cycloaddition of methylideneaniline N-oxide to sugar enones is described. The addition occurred exclusively from the side opposite to the aglycone affording the corresponding alkyl α-D-lyxo-hexopyranosid-(2,3:5′,4′)-phenylisoxazolidin-4- ulose
Synthesis, Configurational and Conformational Studies of Six Amino Sugar Precursors Formed by [3+2] Cycloaddition of Alkylnitrile Oxides to Enone Sugars
Filho, Joao R. de Freitas,Cottier, Louis,Srivastava, Rajendra M.,Sinou, Denis
, p. 1358 - 1360 (2007/10/03)
An easy and efficient synthesis of a novel bicyclic system (isoxazolino-pyranoside), obtained by the 1,3-dipolar cycloaddition of acetonitrile and propionitrile oxides to highly reactive α,β-unsaturated sugar enones, is described. The configuration and co
Synthesis of 2,3-unsaturated 4-amino sugars and cyclohexyl 2,3-di-O-acetyl-4,6-di-O-methyl-α-D-mannopyranoside from cyclohexyl 4,6-di-O-acetyl-2,3-dideoxy-α-D-erythro-hex-2-enopyranoside
De Brito, Tania M.B.,Da Silva, Ladjane P.,Siqueira, Valdenis L.,Srivastava
, p. 609 - 616 (2007/10/03)
The synthesis of three 2,3-unsaturated 4-amino sugars 2-4 and cyclohexyl 2,3-di-O-acetyl-4,6-di-O-methyl-α-D-mannopyranoside 8 starting from cyclohexyl 4,6-di-O-acetyl-2,3-dideoxy-α-D-erythro-hex-2-enopyranoside 1 is described. The amino sugars were prepa
