447452-27-9Relevant academic research and scientific papers
Synthesis of new branched-chain amino sugars
De Freitas Filho, Joao R.,Srivastava, Rajendra M.,Da Silva, Waldenberg J.P.,Cottier, Louis,Sinou, Denis
, p. 673 - 680 (2003)
1,3-Dipolar cycloaddition of methylideneaniline N-oxide to sugar enones is described. The addition occurred exclusively from the side opposite to the aglycone affording the corresponding alkyl α-D-lyxo-hexopyranosid-(2,3:5′,4′)-phenylisoxazolidin-4- ulose
Structure-based design, synthesis and antitumoral evaluation of enulosides
Santos, Jonh A.M.,Santos, Cosme S.,Almeida, Claudia L.A.,Silva, Thiago D.S.,Freitas Filho, Jo?o R.,Milit?o, Gardenia C.G.,da Silva, Teresinha G.,da Cruz, Carlos H.B.,Freitas, Juliano C.R.,Menezes, Paulo H.
, p. 192 - 201 (2017/02/15)
Enulosides, carbohydrate derivatives containing an α,β-unsaturated carbonyl unit, were designed and obtained in high yields and isomeric purity. All synthesized compounds exhibited antitumoral activity in micromolar range against four tested tumor cells lines, being the best results observed for HL-60?cells. These compounds open new possibilities to prepare an array of more active, site-specific or selective antitumor agents. 2016 Elsevier Ltd. All rights reserved.
