243140-08-1Relevant academic research and scientific papers
RuO4-mediated oxidation of secondary amines. Part 1. Are hydroxylamines the main intermediates?
Florea, Cristina A.,Petride, Horia
, p. 475 - 486 (2016/07/20)
The RuO4-catalyzed oxidation of secondary amines Bn-NH-CH2R (1a and b; R=H, Me) gave mainly amides, but minute amounts of nitrones PhCH=N(O)-CH2R (9a and b) and traces of Bn-N(OH)-CH2R (R=H, 4a) were also detect
NOVEL BIS-INDOLIC DERIVATIVES, A PROCESS FOR PREPARING THE SAME AND THEIR USES AS A DRUG
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Paragraph 0294; 0295, (2013/03/26)
The present invention relates to novel bis-indolic derivatives, processes for their preparation, and their potential use as new antibacterial drugs.
Novel bis-indolic derivatives, their uses in particular as antibacterials
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Paragraph 0232-0233, (2013/03/26)
The present invention relates to novel bis-indolic derivatives, processes for their preparation, and their potential use as new antibacterial drugs.
BIS-INDOLIC DERIVATIVES, A PROCESS FOR PREPARING THE SAME AND THEIR USES AS A DRUG
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Page/Page column 59, (2013/03/26)
The present invention relates to novel bis-indolic derivatives, processes for their preparation, and their potential use as new antibacterial drugs.
BIS-INDOLIC DERIVATIVES, THEIR USES IN PARTICULAR AS ANTIBACTERIALS
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Page/Page column 42, (2013/03/26)
The present invention relates to novel bis-indolic derivatives, processes for their preparation, and their potential use as new antibacterial drugs.
Molybdenum oxide/bipyridine hybrid material {[MoO3(bipy)] [MoO3(H2O)]}n as catalyst for the oxidation of secondary amines to nitrones
Abrantes, Marta,Gonalves, Isabel S.,Pillinger, Martyn,Vurchio, Carolina,Cordero, Franca M.,Brandi, Alberto
experimental part, p. 7079 - 7082 (2012/01/30)
The inorganic-organic hybrid material {[MoO3(bipy)][MoO 3(H2O)]}n (bipy = 2,2′-bipyridine) can be used as a water-tolerant catalyst for the oxidation of secondary amines under mild conditions using either urea hydrogen peroxide (UHP) or tert-butylhydroperoxide (TBHP) as the oxidant. Under optimized reaction conditions (2 mol % catalyst, 3-4 equiv TBHP, CH2Cl2 as the solvent, 40 °C), the corresponding nitrones were obtained with different efficiency depending on the nature of the cyclic or acyclic amine used.
Reduction of 2,3-dihydroisoxazoles to β-amino ketones and β-amino alcohols
Aschwanden, Patrick,Kvaerno, Lisbet,Geisser, Roger W.,Kleinbeck, Florian,Carreira, Erick M.
, p. 5741 - 5742 (2007/10/03)
(Chemical Equation Presented) We report the reduction of 2,3-dihydroisoxazoles to β-amino ketones and β-amino alcohols. The latter are obtained in high diastereoselectivity with preference for the syn isomer.
Oxidation of secondary amines by molecular oxygen and cyclohexanone monooxygenase
Colonna, Stefano,Pironti, Vincenza,Carrea, Giacomo,Pasta, Piero,Zambianchi, Francesca
, p. 569 - 575 (2007/10/03)
Cyclohexanone monooxygenase from Acinetobacter calcoaceticus catalyzed the oxidation of tertiary and secondary amines to N-oxides and nitrones, respectively. The formation of a hydroxylamine intermediate was involved with secondary amines as starting substrates.
Oxidation of amines catalyzed by cyclohexanone monooxygenase
Colonna, Stefano,Pironti, Vincenza,Pasta, Piero,Zambianchi, Francesca
, p. 869 - 871 (2007/10/03)
Cyclohexanone monooxygenase catalyzed the oxidation of tertiary, secondary and hydroxylamines to N-oxides, hydroxylamines and nitrones respectively.
Regiochemistry and mechanism of oxidation of N-benzyl-N-alkylhydroxylamines to nitrones
Hassan, Azfar,Wazeer, Mohammed I. M.,Saeed, Mohammed T.,Siddiqui, Mohammad N.,Ali, Sk. Asrof
, p. 443 - 451 (2007/10/03)
The oxidation of various N-(o-, m-, p-substituted benzyl)-N-alkylhydroxylamines and their dideuteriobenzyl (PhCD2) counterparts was carried out using mercury(II) oxide and p-benzoquinone (p-BQ) as oxidants. An overwhelming preference for the formation of conjugated nitrones is observed in the oxidation of N-benzyl-N-isopropylhydroxylamines. Considerable intra- and intermolecular kinetic isotope effects and negative ρ values in the Hammet plots point towards a mechanistic pathway that involves electron transfer from nitrogen to the oxidant followed by hydrogen abstraction. The conformation of unstable (E)-nitrones, which readily isomerize to the more stable (Z)-nitrones, is deduced from 1H NMR data. The E ? Z isomerization was found to be a bimolecular process. Copyright
