243140-08-1

Upstream product

• 14321-27-8 N-ethylbenzylamine 
• 7585-47-9 N-benzyl-(S)-alanine 
• 7585-47-9 N-benzylalanine 
• 3376-26-9 N-Benzylidenebenzylamine N-oxide 
• 100-52-7 benzaldehyde 
• 932-90-1 syn-benzaldehyde oxime 
• 65616-26-4 N-benzyl-N-ethylhydroxylamine 
• 75-07-0 acetaldehyde 
• 622-30-0 N-benzyl hydroxylalmine 
• 79-24-3 Nitroethane 
• 1589-82-8 phenylmagnesium bromide 
• 773837-37-9 sodium cyanide 

Downstream Products

• 1373129-29-3 1-benzyl-5-methyl-4-methylenepyrrolidin-2-one 
• 1373129-14-6 benzyl 4-[benzyl(hydroxy)amino]-3-methylenepentanoate 
• 55-21-0 benzamide 
• 100-52-7 benzaldehyde 
• 100-47-0 benzonitrile 
• 1137-96-8 N-(benzylidene)aniline N-oxide 
• 139189-69-8 (3R^*, 3aR^*, 7aR^*)-2-benzyl-3-methyl-4-oxo-tetrahydropyrano<3,4-d>isoxazolidine 
• 872470-57-0 N-benzyl-N-(1-methylhept-2-ynyl)hydroxylamine 
• 872470-34-3 2-benzyl-5-tert-butyl-3-methyl-2,3-dihydroisoxazole 
• 872470-48-9 2-benzyl-3-methyl-5-phenyl-2,3-dihydroisoxazole 
• 872470-33-2 2-benzyl-5-butyl-3-methyl-2,3-dihydroisoxazole 

Relevant academic research and scientific papers

RuO4-mediated oxidation of secondary amines. Part 1. Are hydroxylamines the main intermediates?

The RuO4-catalyzed oxidation of secondary amines Bn-NH-CH2R (1a and b; R=H, Me) gave mainly amides, but minute amounts of nitrones PhCH=N(O)-CH2R (9a and b) and traces of Bn-N(OH)-CH2R (R=H, 4a) were also detect

NOVEL BIS-INDOLIC DERIVATIVES, A PROCESS FOR PREPARING THE SAME AND THEIR USES AS A DRUG

The present invention relates to novel bis-indolic derivatives, processes for their preparation, and their potential use as new antibacterial drugs.

Novel bis-indolic derivatives, their uses in particular as antibacterials

The present invention relates to novel bis-indolic derivatives, processes for their preparation, and their potential use as new antibacterial drugs.

BIS-INDOLIC DERIVATIVES, A PROCESS FOR PREPARING THE SAME AND THEIR USES AS A DRUG

The present invention relates to novel bis-indolic derivatives, processes for their preparation, and their potential use as new antibacterial drugs.

BIS-INDOLIC DERIVATIVES, THEIR USES IN PARTICULAR AS ANTIBACTERIALS

The present invention relates to novel bis-indolic derivatives, processes for their preparation, and their potential use as new antibacterial drugs.

Molybdenum oxide/bipyridine hybrid material {[MoO3(bipy)] [MoO3(H2O)]}n as catalyst for the oxidation of secondary amines to nitrones

The inorganic-organic hybrid material {[MoO3(bipy)][MoO 3(H2O)]}n (bipy = 2,2′-bipyridine) can be used as a water-tolerant catalyst for the oxidation of secondary amines under mild conditions using either urea hydrogen peroxide (UHP) or tert-butylhydroperoxide (TBHP) as the oxidant. Under optimized reaction conditions (2 mol % catalyst, 3-4 equiv TBHP, CH2Cl2 as the solvent, 40 °C), the corresponding nitrones were obtained with different efficiency depending on the nature of the cyclic or acyclic amine used.

Reduction of 2,3-dihydroisoxazoles to β-amino ketones and β-amino alcohols

(Chemical Equation Presented) We report the reduction of 2,3-dihydroisoxazoles to β-amino ketones and β-amino alcohols. The latter are obtained in high diastereoselectivity with preference for the syn isomer.

Oxidation of secondary amines by molecular oxygen and cyclohexanone monooxygenase

Cyclohexanone monooxygenase from Acinetobacter calcoaceticus catalyzed the oxidation of tertiary and secondary amines to N-oxides and nitrones, respectively. The formation of a hydroxylamine intermediate was involved with secondary amines as starting substrates.

Oxidation of amines catalyzed by cyclohexanone monooxygenase

Cyclohexanone monooxygenase catalyzed the oxidation of tertiary, secondary and hydroxylamines to N-oxides, hydroxylamines and nitrones respectively.

Asymmetric synthesis of β-amino acids by addition of chiral enolates to nitrones via N-acyloxyiminium ions

N-Acyloxyiminium ions, generated by the reaction of nitrones with acyl halides, are highly reactive species and undergo facile reaction with a wide range of nucleophiles, such as ketene silyl acetals, titanium(IV) and boron enolates, hydrido- and allyltin(IV) reagents, and alkynyltitanium(IV) reagents, to give α-substituted amine derivatives. Optically active β-amino acids can be prepared by the reaction of N-acyloxyiminium ions with both boron and titanium(IV) enolates bearing chiral auxiliaries. Reversal of diastereoselectivity was observed by the reactions of the boron and titanium(IV) enolates. Using these reactions, all of the four stereoisomers of α-methyl-β-phenylalanines, for example, can be prepared highly diastereoselectively. Cyclic N-acyloxyiminium ions are useful for the asymmetric synthesis of pyrrolidine and piperidine alkaloids; (5R,8R,8aS)-5-cyano-8-methylindolizidine, which is a common key intermediate for synthesis of 5-substituted 8-methylindolizidines, was prepared selectively.