1040272-14-7

Basic information

• Product Name: 1-((1S,3aR,14bS)-2-methoxy-1,5,6,8,9,14b-hexahydro-4H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]cyclopenta[b]pyrrolo[1,2-a]azepin-1-yl) 4-methyl (R)-2-((E)-4-(benzyloxy)-4-methylpent-2-en-1-yl)-2-hydroxysuccinate
• Synonyms: 1-((1S,3aR,14bS)-2-methoxy-1,5,6,8,9,14b-hexahydro-4H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]cyclopenta[b]pyrrolo[1,2-a]azepin-1-yl) 4-methyl (R)-2-((E)-4-(benzyloxy)-4-methylpent-2-en-1-yl)-2-hydroxysuccinate
• CAS NO: 1040272-14-7
• Molecular Weight: 633.739
• Mol File: 1040272-14-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-((1S,3aR,14bS)-2-methoxy-1,5,6,8,9,14b-hexahydro-4H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]cyclopenta[b]pyrrolo[1,2-a]azepin-1-yl) 4-methyl (R)-2-((E)-4-(benzyloxy)-4-methylpent-2-en-1-yl)-2-hydroxysuccinate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-((1S,3aR,14bS)-2-methoxy-1,5,6,8,9,14b-hexahydro-4H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]cyclopenta[b]pyrrolo[1,2-a]azepin-1-yl) 4-methyl (R)-2-((E)-4-(benzyloxy)-4-methylpent-2-en-1-yl)-2-hydroxysuccinate(1040272-14-7)
• EPA Substance Registry System: 1-((1S,3aR,14bS)-2-methoxy-1,5,6,8,9,14b-hexahydro-4H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]cyclopenta[b]pyrrolo[1,2-a]azepin-1-yl) 4-methyl (R)-2-((E)-4-(benzyloxy)-4-methylpent-2-en-1-yl)-2-hydroxysuccinate(1040272-14-7)

Safety Data

• Hazardous Substances Data: 1040272-14-7(Hazardous Substances Data)

Upstream product

• 38750-57-1 (±)-cephalotaxinone 
• 62681-68-9 1-(benzo[d][1,3]dioxol-5-yl)ethan-1-one oxime 
• 38750-57-1 (-)-Cephalotaxinone 
• 24316-19-6 cephalotaxine 
• 51020-45-2 (3aS)-5,6,8,9-Tetrahydro-1-hydroxy-4H-cyclopenta<1,3>dioxolo<4,5-h>pyrrolo<2,1-b><3>benzazepin-2(3H)-one 
• 26902-24-9 3-(benzyloxy)-3-methyl-1-butene 
• 910138-87-3 C₃₀H₃₃NO₉ 
• 1040272-07-8 C₂₆H₂₄O₈ 
• 1040272-09-0 (R,E)-benzyl 2-(4-(benzyloxy)-4-methylpent-2-enyl)-4-oxooxetane-2-carboxylate 
• 1040272-12-5 (R,E)-2-(4-(benzyloxy)-4-methylpent-2-enyl)-4-oxooxetane-2-carboxylic acid 
• 3162-29-6 1-(benzo[d][1,3]dioxol-6-yl)ethanone 
• 62681-67-8 2-(benzo[1,3]dioxol-5-yl)aziridine 
• 910138-88-4 C₃₀H₃₁NO₉ 
• 910138-81-7 C₃₁H₃₅NO₈S 

Downstream Products

• 26833-87-4 homoharringtonine 

Relevant articles and documents

ANALOGUES AND DERIVATIVES OF CEPHALOTAXINE AND METHODS FOR MAKING AND USING THE COMPOUNDS

Disclosed herein are embodiments of a compound having a Formula I, or a salt, solvate, N-oxide, prodrug, diastereomer or enantiomer thereof. Also disclosed are derivative compounds made from the compound of Formula I. Certain derivative compounds have a Formula V-2, or a salt, solvate, N-oxide, prodrug, diastereomer or enantiomer thereoAlso disclosed are method for making and using the disclosed compounds. Certain disclosed embodiments are useful for treating and/or preventing certain diseases and/or disorders, including proliferation diseases, such as leukemia.

CEPHALOTAXUS ESTERS, METHODS OF SYNTHESIS, AND USES THEREOF

The present invention provides novel cephalotaxus esters, syntheses thereof, and intermediates thereto. The invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of using said compounds or compositions in the treatment of proliferative diseases (e.g., benign neoplasm, cancer, inflammatory disease, autoimmune disease, diabetic retinopathy) and infectious disease. The invention further provides methods of using said compounds or compositions in the treatment of multidrug resistant cancer.