24325-96-0

Upstream product

• 25109-76-6 2,3-dibromobutanenitrile 
• 75-31-0 isopropylamine 
• 4786-20-3 crotononitrile 
• 7726-95-6 bromine 
• 100-46-9 benzylamine 

Downstream Products

• 24325-95-9 (E)-2-bromobut-2-enenitrile 
• 99275-80-6 1-Cyclohexyl-3-methyl-aziridine-2-carbonitrile 
• 882-33-7 diphenyldisulfane 
• 21017-29-8 (Z)-3-phenoxy-2-butenenitrile 
• 21017-30-1 (E)-3-phenoxy-2-butenenitrile 

Relevant academic research and scientific papers

Preparation of α-haloacrylate derivatives via dimethyl sulfoxide-mediated selective dehydrohalogenation

(Chemical Equation Presented) Dimethyl sulfoxide causes α/β-dihalopropanoate derivatives to undergo efficient, selective dehydrohalogenation to form α-haloacrylate analogues. A variety of α-halo Michael acceptors were prepared in dimethyl sulfoxide under mild, base-free conditions, including the preparation of α-bromoacrolein and α-chloro- and bromoacrylonitriles. Synthesis of these molecules has been reported in the literature to be difficult. Among all the existing dehydrohalogenation procedures, this protocol is the most facile, practical, and environmentally benign process.

Elimination reaction over solid supports under microwave irradiation: Synthesis of functionalized alkenes

Treatment of 1,2-dibromocompounds with KF supported on alumina, or bentonite/E13N under microwave irradiation leads to an elimination reaction which produces functionalized alkenes in fair yields.

A Rapid Synthesis of Aziridine Derivatives over Bentonite in 'Dry Media'

Functionalized aziridines are synthesized from dibromo compounds and primary aliphatic amines in the absence of solvent over bentonite as a solid support; in some examples microwave activation is compared to normal heating.