25109-76-6Relevant articles and documents
Schroeder et al.
, p. 3181 (1970)
A PROCESS FOR PREPARATION OF TRIAMINOPYRIMIDINE COMPOUND AND INTERMEDIATES THEREOF
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Page/Page column 34, (2019/04/10)
The present invention relates to triaminopyrimidine compound 1, or pharmaceutically acceptable salts thereof, or hydrates, or solvates, or polymorphs, or optically active forms thereof, in solid state forms. The invention also relates to a process for preparation of triaminopyrimidine compound and intermediates thereof. The present invention also relates to a pharmaceutical composition comprising pure triaminopyrimidine compound, useful for preventing or treating malaria.
Ni-Catalyzed C-H Functionalization in the Formation of a Complex Heterocycle: Synthesis of the Potent JAK2 Inhibitor BMS-911543
Fitzgerald, Monica A,Soltani, Omid,Wei, Carolyn,Skliar, Dimitri,Zheng, Bin,Li, Jun,Albrecht, Jacob,Schmidt, Michael,Mahoney, Michelle,Fox, Richard J.,Tran, Kristy,Zhu, Keming,Eastgate, Martin D.
, p. 6001 - 6011 (2015/06/30)
BMS-911543 is a complex pyrrolopyridine investigated as a potential treatment for myeloproliferative disorders. The development of a short and efficient synthesis of this molecule is described. During the course of our studies, a Ni-mediated C-N bond formation was invented, which enabled the rapid construction of the highly substituted 2-aminopyridine core. The synthesis of this complex, nitrogen-rich heterocycle was accomplished in only eight steps starting from readily available materials.
