24327-72-8

Upstream product

• 533-02-8 (E)-N'-benzylideneisonicotinohydrazide 
• 68-11-1 mercaptoacetic acid 
• 71-43-2 benzene 
• 54-85-3 isoniazid 
• 100-52-7 benzaldehyde 

Downstream Products

• 936097-69-7 5-(4-chlorobenzylidene)-3-isonicotinamido-2-phenyl-[1,3]thiazolidin-4-one 

Relevant academic research and scientific papers

Application of new isonicotinamides as a corrosion inhibitor on mild steel in acidic medium: Electrochemical, SEM, EDX, AFM and DFT investigations

Corrosion inhibition effect of 2-(2-(2-phenyl)-3-(isonicotinamido)-4-oxothiazolidin-5-yl) acetic acid (PITA) and N-(2-phenyl-4-oxothiazolidin-3-yl)-isonicotinamide (POTI) on mild steel corrosion in 15% HCl solution was studied by using weight loss, electrochemical polarization and electrochemical impedance spectroscopy (EIS) techniques. It was found that the inhibition efficiency of both inhibitors increases with increase in concentration. The effect of temperature on the corrosion rate was investigated and some thermodynamic parameters were calculated. Polarization studies show that both studied inhibitors are of mixed type in nature. The results show that both POTI and PITA are good inhibitors, and the adsorption of each inhibitor on mild steel surface obeys Langmuir adsorption isotherm. Scanning electron microscopic (SEM), energy dispersive X-ray spectroscopic (EDX) and atomic force microscopy (AFM) studies were used to characterize the surface morphology of uninhibited and inhibited mild steel specimens. The morphological study indicated adsorption of inhibitor molecules on the surface of the mild steel. The density functional theory (DFT) was employed for theoretical calculations. The results obtained from experimental measurements and those from theoretical calculations are in good agreement.

An efficient alkynylation of 4-thiazolidinone with terminal alkyne under C-H functionalisation

A method of palladium catalysed efficient alkynylation through the cross coupling reaction of terminal alkynes with the slightly more acidic C-H bonds of 4-thiazolidinone has been developed. This method allows the direct introduction of an ethynyl group into the 4-thiazolidinone moiety. Mild reaction conditions involving aerial oxidation and one pot synthesis make this reaction more efficient for the formation of sp3(C)-sp(C) bond.

Synthesis and antimicrobial activity of N-[2-(aryl/substituted aryl)-4-oxo-1,3-thiazolidin-3-yl]pyridine-4-carboxamide

A series of isonicotinyl hydrazones and their 4-thiazolidinones have been synthesized by condensation of isonicotinic acid hydrazide with various aromatic aldehydes to yield Schiff's bases, followed by the cyclocondensation of Schiff's bases with 2-mercaptoacetic acid to yield their 4-thiazolidinones. The synthesized compounds have been characterized by their elemental, analytical and spectral studies. All these compounds were evaluated for their invitro antimicrobial activity against a spectrum of non-resistant and resistant microbial organisms. These studies proved that compounds 5e,i against B. subtilis; 5e,f,h against B. anthracis; 5g,i against S. aureus showed good activity at lower concentrations. Compounds 5d-5i displayed significant activity against resistant strain of K. pneumonia with minimum inhibitory potency in the concentration range of 2-16 ug/ml.

An efficient and convenient protocol for the synthesis of thiazolidin-4-ones

Without a catalyst and under solvent-free conditions, 2,3-disubstituted-1, 3- thiazolidin-4-one 5a-j derivatives were synthesized efficiently via the three-component reaction of aryl hydrazide, aromatic aldehyde, and mercaptoacetic acid. All the newly synthesized compounds were confirmed by IR, 1H NMR, and 13C NMR spectroscopy and elemental analysis. Copyright Taylor & Francis Group, LLC.

Synthesis and antimycobacterial activity of a novel series of isonicotinylhydrazide derivatives

A novel series of 14 new isonicotinyl hydrazide derivatives 2a-g, 3a-g containing a 4-thiazolidinone / 2-azetidinone nucleus were synthesized by reacting N9-substituted arylidene / heteroarylidene isonicotinyl hydrazide 1a-g with thioglycollic acid in the presence of dry benzene and with chloroacetyl chloride in the presence of triethylamine, respectively. Structures of all newly synthesized compounds were characterized on the basis of elemental analyses and spectral data (IR and 1H-NMR). All the title compounds were tested for their in-vitro antimycobacterial activity against Mycobacterium tuberculosis H 37Rv using Alamar-Blue susceptibility test, and the activity is expressed as the minimum inhibitory concentration (MIC) in μg/mL. Among the series, compounds 2b, 2g, 3b, and 3g displayed an encouraging antimycobacterial activity profile as compared to that of the reference drugs isoniazid / rifampicin.

Synthesis and antimicrobial activity of 5-amino-2,7-diaryl-6-cyano-3- isonicotinamido thiazolo[4,5-b]-2,3,4,7-tetrahydropyridines, 2,7-diaryl-6-cyano-3-isonicotinamidothiazolo[4,5-b]-2,3,4,5,6, 7-hexahydropyrid-5-ones, 2,7-diaryl-5-amino-3-isonicotinamido

5-Amino-2,7-diaryl-6-cyano-3-isonicotinamido thiazolo[4,5-b]-2,3,4,7- tetrahydropyridines 3 and 2,7-diaryI-6-cyano-3-isonicotinamido thiazolo[4,5-b]-2,3,4,5,6,7-hexahydropyrid-5-ones 4 have been prepared by Michael addition between α,βunsaturated ketones