88090-93-1Relevant academic research and scientific papers
RING-TRANSFORMATION EQUILIBRIUM WITH PARTICIPATION OF ?-BONDED S(IV) IN AN ISOTHIAZOLE SYSTEM. SYNTHESIS OF NON-RING-TRANSFORMED 5-(2-AMINOVINYL)ISOTHIAZOLE DERIVATIVE VIA 1,3-SILYL GROUP SHIFT
Ohkata, Katsuo,Ohyama, Yoshihiko,Watanabe, Yuko,Akiba, Kin-ya
, p. 4561 - 4564 (2007/10/02)
Substituents at 5-position of 5-amino-3-methyl- and 3-p-chlorophenyl-5-methylisothiazoles (7 and 8) were silylated and then lithiated to couple with aromatic nitriles in order to afford the adducts (4 and 5) via 1,3-silyl group shift.Desilylation of 5 wit
RING-TRANSFORMATION FROM ISOTHIAZOLE TO 1,2,4-THIADIAZOLE - POSSIBLE INTERMEDIACY OF ?-SULFURANE
Akiba, Kin-Ya,Noda, Akiko,Ohkata, Katsuo
, p. 111 - 118 (2007/10/02)
5-Amino-3-methyl- and 5-amino-3-phenylisothiazoles (3a and 3b) afforded 1:1 adducts with aromatic nitriles and imidates.On the basis of their spectral data and the structure of hydrolysis products, the adducts were identified as 3-substituted 5-(2-aminovinyl)-1,2,4-thiadiazole derivatives (2a-g), where ring transformation took place from isothiazole to 1,2,4-thiadiazole.
