243468-87-3

Upstream product

• 209251-26-3 (2R,3R,4R)-1-[(para-methoxybenxyl)oxy]-2,4-dimethyl-3-hexanol 
• 243468-86-2 tert-Butyl-{(1S,2S)-1-[(R)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-2-methyl-but-3-enyloxy}-dimethyl-silane 
• 209251-62-7 (2R,3S,4S)-1-[(para-methoxybenxyl)oxy]-2,4-dimethyl-3-hexanol 
• 160238-46-0 (2R)-3-(4-methoxybenzyloxy)-2-methyl-1-propanal 
• 243468-76-0 (3S,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-6-(4-methoxy-benzyloxy)-3,5-dimethyl-hexan-1-ol 
• 69739-34-0 t-butyldimethylsiyl triflate 

Downstream Products

• 442899-68-5 (2Z,4E,10E,12E)-(6R,7S,8S,14S,15R,16S,17S,18R,19R)-17-(tert-Butyl-dimethyl-silanyloxy)-19-(3,4-dimethoxy-benzyloxy)-7-hydroxy-2,14-dimethoxy-4,6,8,10,16,18-hexamethyl-15-triethylsilanyloxy-icosa-2,4,10,12-tetraenoic acid methyl ester 
• 243468-89-5 tert-Butyl-{(1S,2S)-1-[(R)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-2-methyl-pent-4-ynyloxy}-dimethyl-silane 
• 88899-55-2 bafilomycin A₁ 
• 243468-88-4 tert-Butyl-{(1S,2S)-5,5-dibromo-1-[(R)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-2-methyl-pent-4-enyloxy}-dimethyl-silane 

Relevant academic research and scientific papers

Total synthesis of (-)-bafilomycin A1

A highly stereoselective total synthesis of (-)-bafilomycin A1, the naturally occurring enantiomer of this potent vacuolar ATPase inhibitor, is described. The synthesis features the highly stereoselective aldol reaction of methyl ketone 8b and