2435557-99-4 Usage
Uses
Used in Pharmaceutical Research and Development:
(R)-7-bromo-N-(4-hydroxyphenethyl)-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazoline-1-carboxamide is used as a potential candidate in pharmaceutical research and development for its complex molecular structure and stereochemistry. (R)-7-bromo-N-(4-hydroxyphenethyl)-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazoline-1-carboxamide's unique arrangement of atoms and functional groups may offer novel pharmacological properties, making it a valuable asset in the search for new therapeutic agents.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (R)-7-bromo-N-(4-hydroxyphenethyl)-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazoline-1-carboxamide is used as a starting point for the design and synthesis of new drugs. Its intricate structure and stereochemistry may provide insights into the development of more effective and targeted therapeutics.
Used in Biological Activity Studies:
(R)-7-bromo-N-(4-hydroxyphenethyl)-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazoline-1-carboxamide is utilized in biological activity studies to explore its potential interactions with biological targets, such as receptors, enzymes, or other proteins. Understanding these interactions can help researchers determine the compound's suitability for various therapeutic applications.
Used in Drug Design and Optimization:
In the context of drug design and optimization, (R)-7-bromo-N-(4-hydroxyphenethyl)-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazoline-1-carboxamide serves as a structural template for the development of new drugs. Its unique features may be leveraged to improve the potency, selectivity, and pharmacokinetic properties of future therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 2435557-99-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 2,4,3,5,5,5 and 7 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 2435557-99:
(9*2)+(8*4)+(7*3)+(6*5)+(5*5)+(4*5)+(3*7)+(2*9)+(1*9)=194
194 % 10 = 4
So 2435557-99-4 is a valid CAS Registry Number.
2435557-99-4Relevant academic research and scientific papers
Zhang, Linkui,Zhao, Ying,Wang, Jian,Yang, Donglin,Zhao, Chenwen,Wang, Changli,Ma, Chao,Cheng, Maosheng
, p. 27 - 38 (2018)
Diverse of 1,2,3,9-tetrahydropyrrolo[2,1-b]quinazoline-1-carboxylic acid derivatives were designed, synthesized and evaluated for their neuroprotective activity against NMDA-induced cytotoxicity in vitro, and 5q exhibited excellent neuroprotective activity. The compound 5q was selected for further investigation. We found that 5q could attenuate Ca2+ influx induced by NMDA, meanwhile, 5q could suppress the NR2B up-regulation and increase p-ERK1/2 expression. The molecular docking results showed that 5q might fit well in the binding pocket of 4 and interact with some key residues in the binding pocket of 1 simultaneously. Besides, 5q exhibited acceptable metabolic stability. These results suggested that 5q was a promising lead for further development of new potent and orally bioavailable NR2B-selective NMDAR antagonists.
