243640-26-8

Basic information

• Product Name: 1-Piperidinecarboxylic acid, 4-[(2,3-dimethoxyphenyl)hydroxymethyl]-, 1,1-dimethylethyl ester
• CAS NO: 243640-26-8
• Molecular Formula: C19H29NO5
• Molecular Weight: 351.443
• Mol File: 243640-26-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-Piperidinecarboxylic acid, 4-[(2,3-dimethoxyphenyl)hydroxymethyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinecarboxylic acid, 4-[(2,3-dimethoxyphenyl)hydroxymethyl]-, 1,1-dimethylethyl ester(243640-26-8)
• EPA Substance Registry System: 1-Piperidinecarboxylic acid, 4-[(2,3-dimethoxyphenyl)hydroxymethyl]-, 1,1-dimethylethyl ester(243640-26-8)

Safety Data

• Hazardous Substances Data: 243640-26-8(Hazardous Substances Data)

Upstream product

• 139290-71-4 4-(2,3-Dimethoxybenzoyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester 
• 91-16-7 1,2-dimethoxybenzene 
• 137076-22-3 tert butyl 4-formylpiperidine-1-carboxylate 
• 139290-70-3 tert-butyl 4-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 498-94-2 isonipecotic acid 
• 84358-13-4 N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid 
• 280115-99-3 tert-butyl 4-(chlorocarbonyl)-piperidine-1-carboxylate 

Downstream Products

• 140235-25-2 (+/-)-α-(2,3-dimethoxyphenyl)-4-piperidinemethanol 

Relevant articles and documents

Highly enantioselective hydrogenation and transfer hydrogenation of cycloalkyl and heterocyclic ketones catalysed by an iridium complex of a tridentate phosphine-diamine ligand

Ir complexes of chiral phosphine-diamine ligands catalyse the hydrogenation and transfer hydrogenation of aryl-piperidin-4-yl methanones, and ketones bearing both an aryl group and secondary alkyl substituent with up to 98% e.e., and with substrate to catalyst ratios of up to 4000.

Processes for the preparation of (R)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol"

The present invention provides various processes for the preparation of (R)-±-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol. These processes may be characterized by the following scheme: