243645-12-7

Upstream product

• 678-39-7 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 243645-06-9 tert-butyl-phenyl-1H,1H,2H,2H-heptadecafluorodecyloxysilyl ether 
• 243645-07-0 tert-butyl-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-decyloxy)-phenyl-(3-phenyl-allyloxy)-silane 
• 243645-11-6 tert-butyl-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-decyloxy)-(1-methyl-2-phenyl-ethoxy)-phenyl-silane 
• 243645-01-4 tert-butyl-phenyl-1H,1H,2H,2H-heptadecafluorodecyloxysilyl bromide 
• 917495-81-9 N-(9-{5-[tert-butyl-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-decyloxy)-phenyl-silanyloxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide 
• 917495-79-5 N-(9-{5-[tert-butyl-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-decyloxy)-phenyl-silanyloxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide 
• 917495-80-8 N-(1-{5-[tert-butyl-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-decyloxy)-phenyl-silanyloxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-benzamide 
• 871836-78-1 5'-O-[tert-butyl(phenyl)(1H,1H,2H,2H-perfluorodecyloxy)silyl] thymidine 

Relevant academic research and scientific papers

Synthesis and application of fluorous-tagged oligonucleotides

Nucleoside phosphoramidites bearing a adsorbent tert-butylphenyl-1H,1H,2H, 2H-heptafluorodecyloxysilyl (BPFOS) group were used to synthesize fluorous-tagged oligonucleotides, viz. 5-mer, 10-mer, 13-mer, 17-mer, and 19-mer, which were subjected to liquid-p

Synthesis and applications of fluorous silyl protecting groups with improved acid stability

Fluorous alkoxysilyl protecting groups have been developed and evaluated for their acid stability. tert-Butylphenyl-1H,1H,2H,2H-heptadecafluorodecyloxysilyl (BPFOS) ethers in particular were found to be surprisingly acid stable and allow simple protection-purification-deprotection schemes by liquid-liquid extraction with FC-72/CH3CN or by solid phase extraction with fluorous reverse phase silica gel.