243645-01-4

Upstream product

• 678-39-7 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 243645-12-7 tert-butyldiphenylsilyl 1H,1H,2H,2H-perfluorodecyl ether 

Downstream Products

• 243645-11-6 tert-butyl-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-decyloxy)-(1-methyl-2-phenyl-ethoxy)-phenyl-silane 
• 243645-06-9 tert-butyl-phenyl-1H,1H,2H,2H-heptadecafluorodecyloxysilyl ether 
• 658714-97-7 tert-butylphenyl-1H,1H,2H,2H-heptadecafluorodecyloxysilyl 3,4,6-tri-O-acetyl-2-deoxy-2-acetyl-β-D-glucopyranoside 
• 807355-16-4 Acetic acid (2R,3S,4R,5R,6S)-3-acetoxy-2-acetoxymethyl-6-[tert-butyl-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-decyloxy)-phenyl-silanyloxy]-5-(2,2,2-trichloro-ethoxycarbonylamino)-tetrahydro-pyran-4-yl ester 
• 917495-81-9 N-(9-{5-[tert-butyl-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-decyloxy)-phenyl-silanyloxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide 
• 917495-80-8 N-(1-{5-[tert-butyl-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-decyloxy)-phenyl-silanyloxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-benzamide 
• 658714-99-9 tert-butylphenyl-1H,1H,2H,2H-heptadecafluorodecyloxysilyl 4,6-O-benzylidene-2-deoxy-2-acetyl-β-D-glucopyranoside 
• 658714-98-8 tert-butylphenyl-1H,1H,2H,2H-heptadecafluorodecyloxysilyl 2-deoxy-2-acetyl-β-D-glucopyranoside 
• 807355-18-6 {(2R,4aR,6S,7R,8R,8aS)-6-[tert-Butyl-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-decyloxy)-phenyl-silanyloxy]-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl}-carbamic acid 2,2,2-trichloro-ethyl ester 
• 807355-17-5 {(2S,3R,4R,5S,6R)-2-[tert-Butyl-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-decyloxy)-phenyl-silanyloxy]-4,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-3-yl}-carbamic acid 2,2,2-trichloro-ethyl ester 
• 917495-79-5 N-(9-{5-[tert-butyl-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-decyloxy)-phenyl-silanyloxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide 
• 243645-07-0 tert-butyl-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-decyloxy)-phenyl-(3-phenyl-allyloxy)-silane 

Relevant academic research and scientific papers

Synthesis and applications of fluorous silyl protecting groups with improved acid stability

Fluorous alkoxysilyl protecting groups have been developed and evaluated for their acid stability. tert-Butylphenyl-1H,1H,2H,2H-heptadecafluorodecyloxysilyl (BPFOS) ethers in particular were found to be surprisingly acid stable and allow simple protection-purification-deprotection schemes by liquid-liquid extraction with FC-72/CH3CN or by solid phase extraction with fluorous reverse phase silica gel.

Synthesis and application of fluorous-tagged oligonucleotides

Nucleoside phosphoramidites bearing a adsorbent tert-butylphenyl-1H,1H,2H, 2H-heptafluorodecyloxysilyl (BPFOS) group were used to synthesize fluorous-tagged oligonucleotides, viz. 5-mer, 10-mer, 13-mer, 17-mer, and 19-mer, which were subjected to liquid-p