24370-72-7

Upstream product

• 20289-26-3 4-benzyloxy-1H-indole 
• 124-38-9 carbon dioxide 

Downstream Products

• 1149360-88-2 4-(benzyloxy)-N-(2,3-dihydro-1H-inden-5-yl)-1H-indole-3-carboxamide 
• 1149360-87-1 4-(benzyloxy)-N-(4-t-butylphenyl)-1H-indole-3-carboxamide 
• 1149360-84-8 4-(benzyloxy)-N-(3-(trifluoromethyl)phenyl)-1H-indole-3-carboxamide 
• 1149360-83-7 4-(benzyloxy)-N-(4-chlorophenyl)-1H-indole-3-carboxamide 
• 1149360-89-3 N-(4-chlorophenyl)-4-hydroxy-1H-indole-3-carboxamide 
• 1149360-90-6 4-hydroxy-N-(3-(trifluoromethyl)phenyl)-1H-indole-3-carboxamide 
• 1149360-92-8 N-(4-t-butylphenyl)-4-hydroxy-1H-indole-3-carboxamide 
• 1149360-22-4 N-(4-chlorophenyl)-4-(pyridin-4-ylmethoxy)-1H-indole-3-carboxamide 
• 1149360-23-5 4-(pyridin-4-ylmethoxy)-N-(3-(trifluoromethyl)phenyl)-1H-indole-3-carboxamide 
• 1149360-27-9 N-(4-t-butylphenyl)-4-(pyridin-4-ylmethoxy)-1H-indole-3-carboxamide 

Relevant academic research and scientific papers

Lithium tert-butoxide-mediated carboxylation reactions of unprotected indoles and pyrroles with carbon dioxide

Unprotected indoles and pyrroles were found to undergo base-mediated carboxylation reactions under ambient pressure of carbon dioxide. It was found that this transition metal-free carboxylation reaction proceeded smoothly with the use of a large excess of LiOtBu.

Base-mediated carboxylation of unprotected indole derivatives with carbon dioxide

A simple and straightforward method for the preparation of indole-3-carboxylic acids was discovered through the direct carboxylation of indoles with atmospheric pressure of carbon dioxide (CO2) under basic conditions. The key for the reaction was found to be the use of a large excess of LiOtBu as a base to suppress the undesired decarboxylation side reaction.

KDR inhibitor with the intramolecular non-bonded interaction: Conformation-activity relationships of novel indole-3-carboxamide derivatives

We previously reported that compound 1, having a similar conformation to PTK787 (2) by forming a pseudo ring structure with an intramolecular non-bonded S-O interaction, exhibited a potent inhibitory activity against VEGFR2 tyrosine kinase (KDR).1/s