24376-01-0

Basic information

• Product Name: N,N-diethylglycine hydrochloride
• Synonyms: N,N-diethylglycine hydrochloride
• CAS NO: 24376-01-0
• Molecular Formula: C₆H₁₃NO₂*ClH
• Molecular Weight: 167.63386
• EINECS: 246-211-3
• Mol File: 24376-01-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 125-126 °C
• Boiling Point: 203.2°Cat760mmHg
• Flash Point: 76.7°C
• Appearance: /
• Density: g/cm³
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: N,N-diethylglycine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-diethylglycine hydrochloride(24376-01-0)
• EPA Substance Registry System: N,N-diethylglycine hydrochloride(24376-01-0)

Safety Data

• Hazardous Substances Data: 24376-01-0(Hazardous Substances Data)

Usage

Chemical Properties

White crystal

Upstream product

• 2644-21-5 ethyl N,N-diethylglycinate 
• 5292-43-3 bromoacetic acid tert-butyl ester 
• 109-89-7 diethylamine 

Downstream Products

• 66532-86-3 2-(4-acetamidophenoxy)-N,N-diethyl-2-oxaethan-1-aminium chloride 
• 66532-85-2 Prodafalgan 
• 101261-33-0 N,N-diethyl-glycine-(3,4,5-trimethoxy-anilide) 
• 1952-62-1 3-Diaethylaminoacetylamino-10-methyl-phenthiazin 

Relevant articles and documents

N,N′-Dialkylaminoalkylcarbonyl (DAAC) prodrugs and aminoalkylcarbonyl (AAC) prodrugs of 4-hydroxyacetanilide and naltrexone with improved skin permeation properties

N,N′-Dialkylaminoalkylcarbonyl (DAAC) and aminoalkylcarbonyl (AAC) prodrugs of phenolic drugs acetaminophen (APAP) and naltrexone (NTX) are reported. The effects of incorporation of a basic amine group into the promoiety of an acyl prodrug of a phenolic drug on its skin permeation properties are also presented. DAAC-APAP prodrugs were synthesized via a three-step procedure starting with haloalkylcarbonyl esters which were reacted with five different amines: dimethylamine, diethylamine, dipropylamine, morpholine, and piperidine. The spacing between the amino group and the carbonyl group of the acyl group was 1-3 CH2. After the hydrolysis of the ester, the carboxylic acid product was subsequently coupled with the parent drug via a dicyclohexyl carbodiimide (DCC) mediated coupling to yield the DAAC-APAP-HCl prodrugs in excellent yields. The AAC prodrugs were synthesized using commercially available Boc-protected amino acids using DCC or EDCI as coupling agents. The yields of the prodrugs synthesized using these two different methods have been compared. Half-lives (t1/2) of a few members of the DAAC and AAC series were measured in buffer (pH 6.0, 20 mM). The members evaluated in hydrolysis experiments exhibit a t1/2 range of 15-113 min. Among AAC-APAP prodrugs, the isopropyl group in valinate-APAP-HCl exerted a steric effect that increased the t1/2 value for this prodrug compared to alaninate-APAP-HCl or prolinate-APAP-HCl. The 2-morpholinylacetate-APAP prodrug was able to achieve twice the flux of APAP in in vitro diffusion cell experiments through hairless mouse skin.

AMINOACETYLMERCAPTO DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE

The present invention relates to novel aminoacetylmercapto derivatives useful as inhibitors of enkephalinase and ACE.