66532-85-2

Basic information

• Product Name: Propacetamol
• Synonyms: PROPACETAMOL;4-Acetamidophenyl diethylaminoacetate hydrochloride;N，N-Diethylglycine 4-(acetylamino)phenyl ester;Pro-Dafalgan;(Diethylamino)acetic acid 4-(acetylamino)phenyl;4-Acetamidophenyl N,N-diethylglycinate
• CAS NO: 66532-85-2
• Molecular Formula: C₁₄H₂₀N₂O₃
• Molecular Weight: 264.32
• EINECS: 266-390-1
• Mol File: 66532-85-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 55-57 °C
• Boiling Point: 434.457 °C at 760 mmHg
• Flash Point: 216.552 °C
• Appearance: /
• Density: 1.132 g/cm³
• Vapor Pressure: 9.46E-08mmHg at 25°C
• Refractive Index: 1.547
• PKA: 14.20±0.70(Predicted)
• CAS DataBase Reference: Propacetamol(CAS DataBase Reference)
• NIST Chemistry Reference: Propacetamol(66532-85-2)
• EPA Substance Registry System: Propacetamol(66532-85-2)

Safety Data

• Hazardous Substances Data: 66532-85-2(Hazardous Substances Data)

Usage

Description

Propacetamol is the prodrug of paracetamol (acetaminophen), used for intravenous administration. It results from eombination of paracetamol and diethylglycine. Causes contact dermatitis and airborne dermatitis in nurses. Allergenic properties are due to the N,N' -diethylglycine moiety, and not to the paracetamol moiety.

Uses

Propacetamol hydrochloride is a water-soluble prodrug for intravenous administration resulting in the liberation of paracetamol.

Contact allergens

Propacetamol is a prodrug of paracetamol (acetaminophen) used for intravenous administration. It results from the combination of paracetamol and diethylglycine. It caused contact (hand and airborne) dermatitis in nurses and acute systemic dermatitis (pompholyx and nummular dermatitis, generalized eczema, urticaria-like eruption) in nurses who had became sick and received intravenous propacetamol. Allergenic properties are due to the N,N-diethylglycine moiety, and not to the paracetamol moiety. Propacetamol is now substituted by a solution of paracetamol in mannitol (Perfalgan?).

InChI:InChI=1/C14H20N2O3/c1-4-16(5-2)10-14(18)19-13-8-6-12(7-9-13)15-11(3)17/h6-9H,4-5,10H2,1-3H3,(H,15,17)

Upstream product

• 17321-63-0 4-acetamidophenyl 2-chloroacetate 
• 109-89-7 diethylamine 
• 24376-01-0 N,N-diethylaminoacetic acid hydrochloride 
• 2644-21-5 ethyl N,N-diethylglycinate 
• 66532-86-3 2-(4-acetamidophenoxy)-N,N-diethyl-2-oxaethan-1-aminium chloride 

Relevant articles and documents

Propacetamol crystal form and preparation method thereof

The invention discloses a propacetamol crystal form and a preparation method thereof, and relates to the technical field of chemical organic synthesis. Acetaminophen and chloroacetyl chloride are usedas starting materials, the propacetamol crystal form is prepared through a chloroacetylation reaction and an ammoniation reaction, and the propacetamol crystal form is not reported in the prior art Propacetamol solid is prepared by utilizing the preparation method, and therefore, the feeding amount can be accurately controlled when the propacetamol hydrochloride is prepared through a subsequent salt forming reaction, the situation that the dosage of hydrochloric acid is too large or too small is avoided, and the problem that in the prior art, the yield and purity of the product propacetamol hydrochloride are seriously affected when the propacetamol hydrochloride is prepared through a propacetamol oily matter is solved.

P-acetamidophenyl diethylaminoacetate

A p-acetamidophenol derivative which is soluble in water giving stable aqueous solutions. This derivative is p-acetamidophenyl diethylaminoacetate, optionally in the form of a non-toxic pharmaceutically acceptable acid addition salt, particularly the hydrochloride. This derivative rapidly releases the para-acetamidophenol in the organism.