2438-71-3

Basic information

• Product Name: 5-bromo-3-hydrazino-2H-indol-2-one
• Synonyms: 5-bromo-3-hydrazonoindolin-2-one
• CAS NO: 2438-71-3
• Molecular Formula: C₈H₆BrN₃O
• Molecular Weight: 240.0567
• Mol File: 2438-71-3.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 339.3°C at 760 mmHg
• Flash Point: 159°C
• Density: 1.99g/cm³
• Vapor Pressure: 9.28E-05mmHg at 25°C
• Refractive Index: 1.785
• CAS DataBase Reference: 5-bromo-3-hydrazino-2H-indol-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-3-hydrazino-2H-indol-2-one(2438-71-3)
• EPA Substance Registry System: 5-bromo-3-hydrazino-2H-indol-2-one(2438-71-3)

Safety Data

• Hazardous Substances Data: 2438-71-3(Hazardous Substances Data)

Upstream product

• 106-40-1 4-bromo-aniline 
• 66475-83-0 N-(4-bromophenyl)-2-(hydroxyimino) acetamide 
• 87-48-9 5-Bromo-1H-indole-2,3-dione 
• 6326-79-0 6-bromoisatin 
• 443-69-6 5-fluoro-1H-indole-2,3-dione 

Downstream Products

• 20870-78-4 5-bromo-2-indolin-2-one 
• 552332-19-1 5-bromo-3,3-difluoro-2,3-dihydro-1H-indol-2-one 
• 1026942-17-5 (5-Phenyl-[1,3,4]thiadiazol-2-ylsulfanyl)-acetic acid [5-bromo-2-oxo-1,2-dihydro-indol-(3Z)-ylidene]-hydrazide 
• 1026584-33-7 (5-Phenyl-[1,3,4]oxadiazol-2-ylsulfanyl)-acetic acid [5-bromo-2-oxo-1,2-dihydro-indol-(3Z)-ylidene]-hydrazide 
• 180904-63-6 (4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-acetic acid [5-bromo-2-oxo-1,2-dihydro-indol-(3Z)-ylidene]-hydrazide 
• 352461-95-1 Mesoxalic acid dinitrile (4-bromo-2-cyanophenyl) hydrazone 

Relevant articles and documents

Synthesis and pharmacological screening of new isatin-3-[N2-(benzimidazol-1-acetyl)]hydrazone

Twenty new isatin-3-[N2-(benzimidazol-1-acetyl)]hydrazones (IV) were synthesized from ten different isatin-3-[N2–(chloroacetyl)] hydrazones (III) by reacting with benzimidazole and 2-methyl benzimidazole. The intermediates were obtained from isatin hydrazones (II) on condensation with chloroacetyl chloride. These compounds were characterized by IR, 1H NMR and mass spectra. All the compounds were screened for antimicrobial, antioxidant and cytotoxic activity. Some of the new compounds showed promising antibacterial and antifungal activity.

Solvent Effects: Syntheses of 3,3-Difluorooxindoles and 3-Fluorooxindoles from Hydrazonoindolin-2-one by Selectfluor

Efficient syntheses of 3,3-difluorooxindoles and 3-fluorooxindoles via fluorination of hydrazonoindolin-2-one with Selectfluor are reported. Under different solvent conditions, this method produced 3,3-difluorooxindoles and 3-fluorooxindoles selectively. The broad substrate scope and mild reaction conditions make this transformation a valuable method in drug discovery and development.

Lewis acid-promoted direct synthesis of N-unsubstituted hydrazones via the reaction of hydrazine with acetophenone and isatin derivatives

Hydrazones 2–22 were synthesized via the reaction of acetophenone with isatin derivatives and anhydrous hydrazine promoted by BF3 as a Lewis acid at 0°C. Structures of the synthesized hydrazones were determined on the basis of NMR and X-ray crystallograph