243845-91-2

Upstream product

• 5394-13-8 2-bromo-1-benzothiophene 
• 18774-55-5 2-morpholinobenzothiophene 
• 586-75-4 4-chlorobenzoyl chloride 

Downstream Products

• 243845-93-4 (4-bromo-phenyl)-[2-(4-methoxy-phenyl)-benzo[b]thiophen-3-yl]-methanone 
• 63676-08-4 2-(4-methoxyphenyl)benzo[b]thiophen-3-yl 4-[2-(1-piperidyl)ethoxy]phenyl ketone 

Relevant academic research and scientific papers

Synergistic methodologies for the synthesis of 3-aroyl-2- arylbenzo[b]thiophene-based selective estrogen receptor modulators. Two concise syntheses of raloxifene

Difunctionalized benzo[b]thiophene intermediates are prepared which allow fully independent elaboration of the 2-aryl position or the tether position of benzo[b]thiophene-based selective estrogen receptor modulators (SERMs). Two concise syntheses of the SERM raloxifene (Evista) are presented.