63676-08-4

Upstream product

• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 165742-76-7 [2-dimethylamino-6-methoxybenzothien-3-yl] [4-[2-(1-piperidinyl)ethoxy]phenyl]-methanone 
• 40584-57-4 2-(piperidin-1-yl)-1-benzothiophene 
• 403-43-0 4-fluorobenzoyl chloride 
• 111359-29-6 6-methoxy-N,N-dimethylbenzo[b]thiophen-2-amine 
• 586-75-4 4-chlorobenzoyl chloride 
• 243845-88-7 (2-dimethylamino-6-methoxy-benzo[b]thiophen-3-yl)-(4-fluoro-phenyl)-methanone 
• 243845-89-8 (4-bromo-phenyl)-(2-pyrrolidin-1-yl-benzo[b]thiophen-3-yl)-methanone 
• 243845-91-2 (4-bromo-phenyl)-(2-morpholin-4-yl-benzo[b]thiophen-3-yl)-methanone 
• 243845-90-1 (4-bromo-phenyl)-(2-piperidin-1-yl-benzo[b]thiophen-3-yl)-methanone 
• 2008-75-5 N-chloroethylpiperidine hydrochloride 
• 62315-59-7 1-(hydroxyethyl)piperidine sodium alkoxide 
• 243845-93-4 (4-bromo-phenyl)-[2-(4-methoxy-phenyl)-benzo[b]thiophen-3-yl]-methanone 
• 19983-26-7 2-(1-pyrrolidinyl)benzothiophene 

Downstream Products

• 140911-50-8 2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl 4-[2-(1-piperidyl)ethoxy]phenyl ketone 

Relevant academic research and scientific papers

Antithrombotic diamines

This application relates to the use as thrombin inhibitors, coagulation inhibitors and thromboembolic disorder agents of diamines of formula I as defined herein. It also provides novel compounds of formula I, processes and intermediates for their preparation, and pharmaceutical formulations comprising the novel compounds of formula I.

Synergistic methodologies for the synthesis of 3-aroyl-2- arylbenzo[b]thiophene-based selective estrogen receptor modulators. Two concise syntheses of raloxifene

Difunctionalized benzo[b]thiophene intermediates are prepared which allow fully independent elaboration of the 2-aryl position or the tether position of benzo[b]thiophene-based selective estrogen receptor modulators (SERMs). Two concise syntheses of the SERM raloxifene (Evista) are presented.