24393-41-7

Upstream product

• 529-20-4 2-methylphenyl aldehyde 
• 105-56-6 ethyl 2-cyanoacetate 
• 64380-54-7 2-(2-methylphenyl)-1,3-dioxolane 
• 89-95-2 2-methyl-benzyl alcohol 
• 64-17-5 ethanol 
• 99972-36-8 2-cyano-3-o-tolyl-acrylic acid 
• 89-93-0 ortho-methylbenzylamine 
• 6630-33-7 ortho-bromobenzaldehyde 
• 34824-58-3 2-(2-bromophenyl)-1,3-dioxolan 

Downstream Products

• 885982-06-9 4-(2-methylphenyl)piperidine-2,6-dione 
• 59577-81-0 3-(2-methylphenyl)pentan-1,5-dioic acid 
• 630116-52-8 4-(2'-methylphenyl)piperidine 
• 1202403-64-2 C₃₂H₃₉NO₁₀S 
• 1595284-31-3 C₂₄H₂₀N₄O₅ 
• 1013329-83-3 ethyl 2-cyano-3,3-di-o-tolylacrylate 
• 529-20-4 2-methylphenyl aldehyde 

Relevant academic research and scientific papers

Amino Acid Amide based Ionic Liquid as an Efficient Organo-Catalyst for Solvent-free Knoevenagel Condensation at Room Temperature

Abstract: Ionic liquids of amino acid amide were synthesized and used as an efficient catalyst for solvent-free Knoevenagel condensation. Synthesized ionic liquids are an environmentally benign, inexpensive, metal free and plays the dual role of solvent as well as an efficient catalyst for Knoevenagel condensation. A wide range of aliphatic, aromatic and heteroaromatic aldehydes easily undergo condensation with malononitrile and ethyl cyanoacetate. The reaction proceeds at room temperature without using any organic solvent and is very fast with good to excellent yield. Additionally, the catalyst is easily separable and recyclable without loss of activity. Graphic Abstract: [Figure not available: see fulltext.].

Oxidative Olefination of Benzylamine with an Active Methylene Compound Mediated by Hypervalent Iodine (III)

Hypervalent iodine-mediated oxidative olefination of amines with an active methylene compound provides a rapid gateway towards the formation of electrophilic alkenes under mild reaction conditions in good to excellent yields. This is an efficient protocol for the preparation of substituted electrophilic alkenes.

Layered double hydroxide anchored ionic liquids as amphiphilic heterogeneous catalysts for the Knoevenagel condensation reaction

In recent years, great attention has been dedicated to the development of heterogeneous base catalysts providing a green and sustainable process in benign aqueous media. Herein, the ionic liquid modified layered double hydroxide (LDH) based catalysts of L

Fine tuning of catalytic and sorption properties of metal-organic frameworks via in situ ligand exchange

Metal-organic frameworks (MOFs) are gaining considerable attention not only because of their diverse structures but also due to their interesting properties and potential applications. However, fabrication of MOFs with desired structures and properties re

Amine-functionalized ionic liquid-based mesoporous organosilica as a highly efficient nanocatalyst for the Knoevenagel condensation

A novel amine-functionalized ionic liquid-based periodic mesoporous organosilica (PMO-IL-NH2) was prepared and characterized and its catalytic performance was investigated in the Knoevenagel reaction. PMO-IL-NH2 was prepared by simul

Synthesis and characterization of ionic liquid based bifunctional periodic mesoporous organosilica supported potassium carbonate as very efficient nanocatalyst for the Knoevenagel condensation

A novel ionic liquid based bifunctional periodic mesoporous organosilica supported potassium carbonate (BPMO-IL-KCO3) is prepared, characterized and its catalytic efficiency is studied in the Knoevenagel reaction. The BPMO-IL-KCO3 wa

Classical Keggin Intercalated into Layered Double Hydroxides: Facile Preparation and Catalytic Efficiency in Knoevenagel Condensation Reactions

The family of polyoxometalate (POM) intercalated layered double hydroxide (LDH) composite materials has shown great promise for the design of functional materials with numerous applications. It is known that intercalation of the classical Keggin polyoxome

One-pot tandem catalytic synthesis of α, β-unsaturated nitriles from alcohol with nitriles in aqueous phase

Pd1-Au1 bimetal catalysts supported on basic layered double hydroxide (LDH) have been prepared conveniently with surface impregnation methods and structurally characterized by XRD, TEM and XPS. The nanoparticles were highly dispersed on LDH with an average size of 2.08 ± 0.3 nm and showed a strong cooperative effect between Au and Pd for the step of the alcohol oxidation. Moreover, the present hydrotalcite-supported bimetal catalysts can catalyze efficiently one-pot α-arylation reactions of nitriles with various alcohols in aqueous phase through tandem reactions. The bimetal catalyst has been extended for a broad substrate scope and recycled for at least 4 times.

One pot, three-component synthesis of novel 3,4-dihydrophthalazin-2(1H)-yl- 4-phenyl-4H-pyrans

Green and efficient one pot, three-component synthesis of novel 2-amino-6-(1,4-dioxo-3,4-dihydrophthalazin)-2(1H)-yl-4-phenyl-4H-pyran-3, 5-dicarbonitriles 6 has been developed by condensing 3-(1,4-dioxo-3,4- dihydrophthalazin-(1H)-yl)-3-oxopropanenitrile 3, benzaldehydes 4 and active methylene compounds 5 using l-proline as catalyst in EtOH at RT.

Tri-lacunary polyoxometalates of Na8H[PW9O 34] as heterogeneous Lewis base catalysts for Knoevenagel condensation, cyanosilylation and the synthesis of benzoxazole derivatives

We reported for the first time the development of tri-lacunary polyoxometalates (POMs) of Na8H[A-PW9O34] ·7H2O and Na8H[B-PW9O 34]·19H2O (Na-A-PW9 and Na-B-PW 9) as highly selective and efficient heterogeneous Lewis base catalysts for Knoevenagel condensation, cyanosilylation of various aldehydes and ketones and the synthesis of benzoxazole derivatives at 25 C under mild conditions. Since both Na-A-PW9 and Na-B-PW9 display no characteristic porosity, it is proposed that the catalytic reactions proceed not only on the surface and interface, but also in the bulk phase. The catalysts can be easily recovered and reused for at least six times without obvious decrease of catalytic activities and the structures of the catalysts remain unchanged after recycling. The easy preparation, high efficiency, reusability of the heterogeneous catalysts of Na-A-PW9 and Na-B-PW9 exhibit great potential for further application.