59577-81-0

Basic information

• Product Name: 3-(2-methylphenyl)pentan-1,5-dioic acid
• Synonyms: 3-(2-methylphenyl)pentan-1,5-dioic acid
• CAS NO: 59577-81-0
• Molecular Weight: 222.241
• Mol File: 59577-81-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 3-(2-methylphenyl)pentan-1,5-dioic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-methylphenyl)pentan-1,5-dioic acid(59577-81-0)
• EPA Substance Registry System: 3-(2-methylphenyl)pentan-1,5-dioic acid(59577-81-0)

Safety Data

• Hazardous Substances Data: 59577-81-0(Hazardous Substances Data)

Upstream product

• 141-97-9 ethyl acetoacetate 
• 529-20-4 2-methylphenyl aldehyde 
• 24393-41-7 ethyl 2-cyano-3-(2-methylphenyl)acrylate 
• 105-53-3 diethyl malonate 
• 34824-58-3 2-(2-bromophenyl)-1,3-dioxolan 
• 64380-54-7 2-(2-methylphenyl)-1,3-dioxolane 
• 6630-33-7 ortho-bromobenzaldehyde 

Downstream Products

• 1221962-38-4 4-(5-iodo-2-benzimidazolyl)-3-(2-methylphenyl)butanoic acid monohydrochloride 
• 630116-52-8 4-(2'-methylphenyl)piperidine 
• 885982-06-9 4-(2-methylphenyl)piperidine-2,6-dione 

Relevant articles and documents

Synthesis and binding affinities of methylvesamicol analogs for the acetylcholine transporter and sigma receptor

We synthesized methylvesamicol analogs 13-16 and investigated the binding characteristics of 2-[4-phenylpiperidino]cyclohexanol (vesamicol) and methylvesamicol analogs 13-16, with a methyl group introduced into the 4-phenylpiperidine moiety, to sigma receptors (σ-1, σ-2) and to vesicular acetylcholine transporters (VAChT) in membranes of the rat brain and liver. In competitive inhibition studies, (-)-o-methylvesamicol [(-)-OMV] (13) (Ki = 6.7 nM), as well as (-)-vesamicol (Ki = 4.4 nM), had a high affinity for VAChT. (+)-p-Methylvesamicol [(+)-PMV] (16) (Ki = 3.0 nM), as well as SA4503 (Ki = 4.4 nM), reported as a σ-1 mapping agent for positron emission tomography (PET), had a high affinity for the σ-1 receptor. The binding affinity of (+)-PMV (16) for the σ-1 receptor (Ki = 3.0 nM) was about 13 times higher than that for the sigma-2 (σ-2) receptor (Ki = 40.7 nM). (+)-PMV (16) (K i = 199 nM) had a much lower affinity for VAChT than SA4503 (K i = 50.2 nM) and haloperidol (Ki = 41.4 nM). These results showed that the binding characteristics of (-)-OMV (13) to VAChT were similar to those of (-)-vesamicol and that (+)-PMV (16) bound to the σ-1 receptor with high affinity. In conclusion, (-)-OMV (13) and (+)-PMV (16), which had a suitable structure, with a methyl group for labeling with 11C, may become not only a new VAChT ligand and a new type of σ receptor ligand, respectively, but may also become a new target compound of VAChT and the σ-1 receptor radioligand for PET, respectively.

ALLOSTERIC PROTEIN KINASE MODULATORS

The invention provides specific small molecule compounds that allosterically regulate the activity or modulate protein-protein interactions of AGC protein kinases and the Aurora family of protein kinases, methods for their production, pharmaceutical compositions comprising same, and their use for preparing medicaments for the treatment and prevention of diseases related to abnormal activities of AGC protein kinases or of protein kinases of the Aurora family.

LIGAND FOR VESICULAR ACETYLCHOLINE TRANSPORTER

The present invention provides a novel compound represented by the formula (I): wherein R1 and R2 are as defined in the specification, or a salt thereof, which is useful as a reagent (radiotracer) for VAChT mapping and the like, and can be used for positron emission tomography (PET), and a production method of the compound. Moreover, the present invention provides a diagnostic reagent for diagnosing cholinergic neurodegenerative disorders (e.g., Alzheimer's disease, memory disorder, learning disorder, schizophrenia, cognitive dysfunction, hyperactivity disorder, anxiety neurosis, depression, analgia, Parkinson's disease and the like) and the like, which contains the aforementioned compound.