244205-60-5Relevant academic research and scientific papers
Novel N-substituted 2-phenyl-1-sulfonylamino-cyclopropane carboxylates as selective ADAMTS-5 (Aggrecanase-2) inhibitors
Shiozaki, Makoto,Maeda, Katsuya,Miura, Tomoya,Ogoshi, Yosuke,Haas, Julia,Fryer, Andrew M.,Laird, Ellen R.,Littmann, Nicole M.,Andrews, Steven W.,Josey, John A.,Mimura, Takayuki,Shinozaki, Yuichi,Yoshiuchi, Hiromi,Inaba, Takashi
scheme or table, p. 1575 - 1580 (2009/12/07)
A series of N-substituted sulfonylamino-alkanecarboxylate ADAMTS-5 (Aggrecanase-2) inhibitors has been synthesized and the in vitro enzyme SAR is discussed. This report is the first example of carboxylate-based ADAMTS-5 inhibitors which show strong potenc
Asymmetric cyclopropanations by rhodium(II) N-(arylsulfonyl)prolinate catalyzed decomposition of vinyldiazomethanes in the presence of alkenes. Practical enantioselective synthesis of the four stereoisomers of 2-phenylcyclopropan-1-amino acid
Davies, Huw M. L.,Bruzinski, Paul R.,Lake, Debra H.,Kong, Norman,Fall, Michael J.
, p. 6897 - 6907 (2007/10/03)
The rhodium N-(arylsulfonyl)prolinate catalyzed decomposition of vinyldiazomethanes in the presence of alkenes leads to a very general method for the synthesis of functionalized cyclopropanes in a highly diastereoselective and enantioselective mode. A det
