123806-63-3

Basic information

• Product Name: Cyclopropanecarboxylic acid, 1-amino-2-phenyl-, methyl ester, (1R-trans)-
• Synonyms: Cyclopropanecarboxylic acid, 1-amino-2-phenyl-, methyl ester, (1R-trans)-
• CAS NO: 123806-63-3
• Molecular Formula: C₁₁H₁₃NO₂
• Molecular Weight: 191.22642
• Product Categories: AMINOACID
• Mol File: 123806-63-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 279.9±40.0 °C(Predicted)
• Appearance: /
• Density: 1.187±0.06 g/cm3(Predicted)
• PKA: 5.15±0.20(Predicted)
• CAS DataBase Reference: Cyclopropanecarboxylic acid, 1-amino-2-phenyl-, methyl ester, (1R-trans)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopropanecarboxylic acid, 1-amino-2-phenyl-, methyl ester, (1R-trans)-(123806-63-3)
• EPA Substance Registry System: Cyclopropanecarboxylic acid, 1-amino-2-phenyl-, methyl ester, (1R-trans)-(123806-63-3)

Safety Data

• Hazardous Substances Data: 123806-63-3(Hazardous Substances Data)

Upstream product

• 123806-61-1 C₁₉H₁₉NO₄ 
• 86087-20-9 (1R,2S)-1-Benzyloxycarbonylamino-2-phenyl-cyclopropanecarboxylic acid 
• 86014-29-1 N-(benzyloxycarbonyl)-(2RS)-cyclopropyl-E-phenylalanine 
• 1036637-32-7 methyl (1S,2R)-1-nitro-2-phenylcyclopropanecarboxylate 
• 158800-60-3 dimethyl (2S)-2-phenylcyclopropane-1,1-dicarboxylate 
• 180322-77-4 (1S,2S)-(E)-1-carboxy-1-(methoxycarbonyl)-2-phenylcyclopropane 
• 100-42-5 styrene 
• 874341-58-9 methyl (1R,2S)-1-nitro-2-phenylcyclopropanecarboxylate 
• 158800-59-0 (1S,2S)-2-phenyl-1-(pyrrolidin-1-ylcarbonyl)cyclopropanecarboxylic acid 

Downstream Products

• 1374241-52-7 C₁₈H₁₇NO₃ 
• 143900-62-3 C₂₂H₃₂N₂O₅ 
• 143840-55-5 C₂₃H₃₃N₃O₅S 
• 244205-60-5 (1R,2S)-1-tert-Butoxycarbonylamino-2-phenyl-cyclopropanecarboxylic acid 
• 86087-22-1 (+)-(2R)-Cyclopropyl-E-phenylalanine 
• 180322-80-9 methyl (1R,2S)-1-[(tert-butoxycarbonyl)amino]-2-phenylcyclopropanecarboxylate 

Relevant articles and documents

A formyl peptide substituted with a conformationally constrained phenylalanine residue evokes a selective immune response in human neutrophils

Formyl-Met-Leu-Phe-OH (fMLP) binds to formyl peptide receptors, FPR1 and FPR2, and evokes migration and superoxide anion production in human neutrophils. To obtain a more effective and selective ligand, fMLP analogs in which the Phe residue was substitute

Expedient synthesis of cyclopropane α-amino acids by the catalytic asymmetric cyclopropanation of alkenes using iodonium ylides derived from methyl nitroacetate

A highly enantioselective (up to 97.5% ee) and diastereoselective (95:5 dr trans/cis) Cu(I)-catalyzed cyclopropanation of alkenes using phenyliodonium ylide generated in situ from iodosobenzene and methyl nitroacetate is reported. The cyclopropanation took place with high enantioselectivity for a wide range of alkenes, and the reaction was performed at room temperature. 1-Nitrocyclopropyl esters are versatile building blocks to access the corresponding cyclopropane amino esters and aminocyclopropanes in two and three steps, respectively, from commercially available products. Copyright