244229-34-3

Basic information

• Product Name: 1-(2-Bromophenyl)-2,2,2-trifluoroethan-1-one
• Synonyms: 1-(2-Bromophenyl)-2,2,2-trifluoroethan-1-one;2'-Bromo-2,2,2-trifluoroacetophenone;1-(2-Bromo-phenyl)-2,2,2-trifluoro-ethanone;2'-Bromo-2,2,2-trifluoroacetophenone 97%;2-Bromo-α,α,α-trifluoroacetophenone;2'-Bromo-2,2,2-trifluoroacetophenone97%
• CAS NO: 244229-34-3
• Molecular Formula: C₈H₄BrF₃O
• Molecular Weight: 253.0159696
• Mol File: 244229-34-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 230.0±40.0 °C(Predicted)
• Flash Point: 101℃
• Appearance: /
• Density: 1.645 g/mL at 25 °C
• Refractive Index: n20/D1.495
• BRN: 8312425
• CAS DataBase Reference: 1-(2-Bromophenyl)-2,2,2-trifluoroethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-Bromophenyl)-2,2,2-trifluoroethan-1-one(244229-34-3)
• EPA Substance Registry System: 1-(2-Bromophenyl)-2,2,2-trifluoroethan-1-one(244229-34-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 36/37/39
• WGK Germany: 3
• Hazardous Substances Data: 244229-34-3(Hazardous Substances Data)

Usage

General Description

1-(2-Bromophenyl)-2,2,2-trifluoroethan-1-one is a chemical compound that consists of a 2-bromophenyl group attached to a trifluoroethyl ketone group. It is used in various chemical reactions and synthesis processes. The presence of the bromine and trifluoromethyl groups makes this compound a useful building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. Additionally, its unique structure and reactivity make it a valuable intermediate in the production of complex organic molecules. Overall, 1-(2-Bromophenyl)-2,2,2-trifluoroethan-1-one is an important chemical compound with versatile applications in organic synthesis.

Upstream product

• 75-46-7 trifluoromethan 
• 610-94-6 2-bromobenzoic acid methyl ester 
• 394203-55-5 1-(2-bromophenyl)-2,2,2-trifluoroethanol 
• 6630-33-7 ortho-bromobenzaldehyde 
• 383-63-1 ethyl trifluoroacetate, 
• 583-53-9 2,3-dibromobenzene 

Downstream Products

• 244229-36-5 (S)-2,2,2-trifluoro-1-(2-bromophenyl)ethanol 
• 244229-38-7 (R)-2,2,2-trifluoro-1-(2-bromophenyl)ethanol 

Relevant articles and documents

New approach to a novel axially chiral ligand showing spontaneous enrichment of axial chirality.

We have synthesized novel axially chiral ligand with two chiral centers, (R)-(R)(2)- and (S)-(S)(2)-2,2'-bis(2,2,2-trifluoro-1-hydroxyethyl)biphenyl (1), which showed a high asymmetric induction when used as ligand. Here, another new approach to 1 by kine

Visible light-promoted umpolung coupling of aryl tri-/difluoroethanones with 2-alkenylpyridines

Tertiary alcohols bearing a trifluoromethyl group are of considerable medicinal interest. Using an umpolung strategy, we herein report the first intermolecular reductive cross-coupling of aryl tri-/difluoroethanones with 2-alkenylpyridines with the aid of a Br?nsted acid catalyst upon visible-light irradiation. This metal-free reaction is operationally simple and performed at ambient temperature, allowing access to desired tertiary alcohols with tri-/difluoromethyl groups in moderate to excellent yields. The commercially available and easily handled Hantzsch ester effectively serves as an electron donor, as well as a hydrogen atom source.

One-pot multistep synthesis of trisubstituted alkenes from N -tosylhydrazones and alcohols

A one-pot procedure for the synthesis of trisubstituted alkenes from N-tosylhydrazones and alcohols is reported. This procedure combines the aerobic oxidation reaction and Wittig reaction in one pot, which avoids using of environmentally toxic oxidants and isolation of the intermediates. The simple procedure makes it very attractive for the synthesis of trisubstituted alkenes when alcohols are used as starting materials. A variety of trisubstituted alkenes as well as trifluoromethyl-substituted alkenes were obtained in moderate to good yields (up to 84%) with good E-selectivity (up to 99%). Georg Thieme Verlag Stuttgart.New York.