244238-87-7

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 152975-95-6 4-(Ethoxycarbonyl)-1,1-diphenyl-1-methyl-2-aza-1λ⁵-phosphabuta-1,3-diene 

Downstream Products

• 244238-99-1 2-(4-methoxy-phenyl)-1,2-dihydro-pyridine-3,5-dicarboxylic acid 5-ethyl ester 3-methyl ester 

Relevant academic research and scientific papers

Reaction of N-vinylic phosphazenes derived from β-amino acids with aldehydes. Azadiene-mediated synthesis of dihydropyridines, pyridines, and polycyclic nitrogen derivatives

Enamino phosphonium salts 2 are obtained by 1,2-addition of hydrogen chloride to N-vinylic phosphazenes 1 derived from triphenylphosphine. Aza- Wittig reaction of phosphazenes 1 derived from triphenylphosphine and 6 derived from diphenylmethylphosphine with aldehydes 3 leads to the formation of 2-azadienes 7. Reaction of azadienes 7 with enamines affords dihydropyridines 9 and 11, pyridines 12, and bicyclic nitrogen heterocycles 15-18 in a regioselective fashion, while heterodiene 20 reacts in the same way with pyrrolidinocyclohexanone giving 1-azaphenanthrene compound 21. Reaction of enamino phosphonium salts 2 with aldehydes 3 gives symmetrical dihydropyridines 5.

Aza-Wittig reaction of N-vinylic phosphazenes with carbonyl compounds. Azadiene-mediated synthesis of dihydropyridines and pyridines

Aza-Wittig reaction of N-vinylic phosphazenes derived from diphenylmethylphosphine 4 with carbonyl compounds leads to the formation of 2-azadienes derived from β-aminoacids 5. Dimerization of 2-azadienes 5c,d and reaction of compounds 5 with phosphazene 4 or enemine 6 affords substituted dihydropyridines 7 and 8. Aza-Wittig reaction of phosphazenes 4 with α,β-unsaturated aldehydes gives 3-azatrienes 12, which are easily converted into pyridines 13.