244250-56-4

Basic information

• Product Name: (S)-benzyl 2-acetamido-4-methylpentanoate
• Synonyms: (S)-benzyl 2-acetamido-4-methylpentanoate
• CAS NO: 244250-56-4
• Molecular Weight: 263.337
• Mol File: 244250-56-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S)-benzyl 2-acetamido-4-methylpentanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-benzyl 2-acetamido-4-methylpentanoate(244250-56-4)
• EPA Substance Registry System: (S)-benzyl 2-acetamido-4-methylpentanoate(244250-56-4)

Safety Data

• Hazardous Substances Data: 244250-56-4(Hazardous Substances Data)

Upstream product

• 1738-77-8 L-leucine benzyl ester p-toluenesulfonate 
• 64-19-7 acetic acid 
• 108-24-7 acetic anhydride 

Downstream Products

• 1188-21-2 N-Ac-Leu 

Relevant articles and documents

MODULATORS OF SESTRIN-GATOR2 INTERACTION AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

Oligo(4-aminopiperidine-4-carboxylic acid): An unusual basic oligopeptide with an acid-induced helical conformation

In sharp contrast with helical polypeptides carrying basic side chains, Api8, a basic oligopeptide containing the non-natural achiral amino acid 4-aminopiperidine-4-carboxylic acid (Api), adopts a helical conformation only in acidic media. Alkaline titration of a protonated Api8 oligomer appended with a leucine derivative at its N-terminus showed that disruption of its helical conformation occurs in a pH range of 7-10. NMR studies indicated that the piperidine groups in Api8, when nonprotonated, possibly interact with the proximal amide protons in the peptide backbone and hamper the formation of the H-bonding network responsible for the helical conformation. The helical structure is induced not only by protonation but also by acylation of the piperidine groups.