24434-82-0

Basic information

• Product Name: benzo[b]thiophen-3-yl acetate
• Synonyms: benzo[b]thiophen-3-yl acetate;3-ACETOXYTHIANAPHTHENE;3-Acetoxybenzo[b]thiophene;Benzo[b]thiophen-3-ol acetate;Benzo[b]thiophene-3-yl=acetate;Einecs 246-246-4
• CAS NO: 24434-82-0
• Molecular Formula: C₁₀H₈O₂S
• Molecular Weight: 192.23432
• EINECS: 246-246-4
• Mol File: 24434-82-0.mol

Chemical Properties

• Boiling Point: 311.2°Cat760mmHg
• Flash Point: 142°C
• Appearance: /
• Density: 1.275g/cm³
• Vapor Pressure: 0.000574mmHg at 25°C
• Refractive Index: 1.633
• CAS DataBase Reference: benzo[b]thiophen-3-yl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: benzo[b]thiophen-3-yl acetate(24434-82-0)
• EPA Substance Registry System: benzo[b]thiophen-3-yl acetate(24434-82-0)

Safety Data

• Hazardous Substances Data: 24434-82-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H8O2S/c1-7(11)12-9-6-13-10-5-3-2-4-8(9)10/h2-6H,1H3

Upstream product

• 2527-66-4 2-methyl-1,2-benzisothiazole-3(2H)-one 
• 127-08-2 potassium acetate 
• 108-24-7 acetic anhydride 
• 135-13-7 (o-carboxyphenyl)thioacetic acid 
• 119-80-2 2,2'-dithiobenzoic acid 
• 91950-10-6 (2-methylcarbamoyl-phenylsulfanyl)-acetic acid 
• 2527-58-4 2,2'-dithiobis(N-methylbenzamide) 
• 325703-98-8 2-(2-carboxyphenylsulfanyl)-N-phenylacetamide 
• 855934-06-4 (2-benzylcarbamoyl-phenylsulfanyl)-acetic acid 
• 519048-30-7 2-(benzylcarbamoyl-methylsulfanyl)-benzoic acid 
• 130-03-0 thioindoxyl 
• 75-36-5 acetyl chloride 
• 4892-02-8 Methyl thiosalicylate 
• 147-93-3 Thiosalicylic acid 

Downstream Products

• 130-03-0 thioindoxyl 
• 61670-15-3 3-hydroxy-1-benzothiophene-1,1-dioxide 
• 137776-09-1 1-phenyl-1H-benzothieno<3,2-c>pyrazole-3-carbonyl chloride 
• 137776-08-0 1-phenyl-1H-benzothieno<3,2-c>pyrazole-3-carboxylic acid 
• 137776-07-9 1-phenyl-1H-benzothieno<3,2-c>pyrazole-3-carboxylic acid ethyl ester 
• 127477-14-9 2-cyano-3-oxo-3-(1-phenyl-1H-benzothieno<3,2-c>pyrazol-3-yl)-N-phenyl-propanamide 

Relevant articles and documents

Efficient synthesis and 5-LOX/COX-inhibitory activity of some 3-hydroxybenzo[b]thiophene-2-carboxylic acid derivatives

A series of 3-hydroxybenzo[b]thiophene-2-carboxylic acid derivatives has been prepared and subsequently evaluated with regards to the inhibition of 5-LOX/COX. Structure optimization furnished derivatives with promising in vitro activity as dual 5-LOX/COX inhibitors with submicromolar IC50 values for inhibition of 5-LOX and COX-1, respectively.

Application of directed metalation in synthesis. Part 8: Interesting example of chemoselectivity in the synthesis of thioaurones and hydroxy ketones and a novel anionic ortho-Fries rearrangement used as a tool in the synthesis of thienopyranones and thiafluorenones

Chemoselective synthesis of thioaurones or 3-hydroxy benzo[b]thiophen-2- aryl ketones, 1-hydroxy naphtho[2,1-b]thiophen-2-aryl ketones and chalcones from N,N-diethyl-ortho-methyl sulfanyl aryl amides were described. (Benzo[b]thiophen-2-yl) alkylates and (naphtho[2,1-b]thiophen-2-yl) alkylates undergo a novel anionic ortho-Fries rearrangement leading to (3-hydroxy benzo[b]thiophen-2-yl) and (1-hydroxy naphtho[2,1-b]thiophen-2-yl) alkyl ketones. The hydroxy ketones were used as intermediates in the synthesis of wide range of benzothienopyranones and thiafluorenones.

Application of directed metalation in synthesis. Part 7: Synthesis of suitably functionalised benzo[b]thiophenes as key intermediates in the synthesis of benzothienopyranones

One-pot syntheses of (3-hydroxybenzo[b]thiophen-2-yl) aryl methanones from ortho-methylsulfanylaryl N,N-diethyl amides and of 1-(3-hydroxybenzo[b]thiophen- 2-yl)ethanone and 1-(3-hydroxybenzo[b]thiophen-2-yl)propan-1-one via an anionic ortho-Fries rearrangement are described. The hydroxy ketones were used as key intermediates in the synthesis of benzothienopyranones.