24467-36-5Relevant academic research and scientific papers
Study on the diastereoselective synthesis of dithymidine phosphorothioates through a D-xylose derived chiral auxiliary and development of a novel catalyst
Lu,Just
, p. 9223 - 9227 (2000)
1,2-Di-O-isopropylidene-3-C-cyanoethyl-5-deoxy-5-isopropylamino-D-xylofuranos e 16a was synthesized. The use of 16a as a chiral auxiliary led to the diastereoselective formation of dithymidine phosphorothioate. The chiral auxiliary was easily removed by treatment with concentrated ammonia. 2-Mesityl-4,5-dicyanoimidazole displays higher diastereoselectivity than the 2-bromo-4,5-dicyanoimidazole in the coupling reaction. (C) 2000 Elsevier Science Ltd.
