20590-54-9

Basic information

• Product Name: 1,2-O-isopropylidene-5-O-(triphenylmethyl)-α-D-erythro-pentofuranos-3-ulose
• Synonyms: 1,2-O-isopropylidene-5-O-(triphenylmethyl)-α-D-erythro-pentofuranos-3-ulose
• CAS NO: 20590-54-9
• Molecular Weight: 430.5
• Mol File: 20590-54-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1,2-O-isopropylidene-5-O-(triphenylmethyl)-α-D-erythro-pentofuranos-3-ulose(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-O-isopropylidene-5-O-(triphenylmethyl)-α-D-erythro-pentofuranos-3-ulose(20590-54-9)
• EPA Substance Registry System: 1,2-O-isopropylidene-5-O-(triphenylmethyl)-α-D-erythro-pentofuranos-3-ulose(20590-54-9)

Safety Data

• Hazardous Substances Data: 20590-54-9(Hazardous Substances Data)

Upstream product

• 532-20-7 D-xylofuranose 
• 87-72-9 D-Xylose 
• 76-83-5 trityl chloride 
• 20590-53-8 1,2-O-isopropylidene-5-O-trityl-α-D-xylofuranose 

Downstream Products

• 58399-76-1 3-Deoxy-3-C-(2'-hydroxyethyl)-1,2-O-isopropylidene-5-O-(triphenylmethyl)-α-D-ribofuranose 
• 134454-62-9 (E)-methyl 2-((3aR,5S,6aR)-2,2-dimethyl-5-((trityloxy)methyl)furo[2,3-d][1,3]dioxol-6-(3aH,5H,6aH)-ylidene)acetate 
• 134452-54-3 [(3aR,5S,6aR)-2,2-Dimethyl-5-trityloxymethyl-dihydro-furo[2,3-d][1,3]dioxol-(6Z)-ylidene]-acetic acid methyl ester 
• 20590-55-0 1,2-O-Isopropyliden-5-O-triphenylmethyl-α-D-erythro-pentofuranosulose-(3)-oxim 
• 292864-74-5 3-deoxy-1,2-O-isopropylidene-3-methylidene-5-O-trityl-α-D-ribofuranose 
• 302582-03-2 3-amino-3-C-cyano-3-deoxy-5-O-trityl-1,2-O-isopropylidene-α-D-xylofuranose 
• 449205-69-0 3-C-cyano-3-deoxy-1,2-O-isopropylidene-3-{[(methoxycarbonyl)methyl]amino}-5-O-trityl-α-D-ribofuranose 
• 721924-45-4 1,2-O-isopropylidene-5-O-trityl-α-D-erythro-pentofuranose-3-spiro-3'-(4'-amino-2'-N-benzyl-5'-phenyl-5'H-2',3'-dihydroisothiazole-1',1'-dioxide) 
• 721924-34-1 3-amino-3-N-benzyl-3-C-cyano-3-deoxy-1,2-O-isopropylidene-3-N-phenylmethanesulfonyl-5-O-trityl-α-D-ribofuranose 
• 721924-47-6 1,2-O-isopropylidene-5-O-trityl-α-D-erythro-pentofuranose-3-spiro-3'-(4'-amino-5'-phenyl-5'H-2',3'-dihydroisothiazole-1',1'-dioxide) 
• 721924-44-3 1,2-O-isopropylidene-5-O-trityl-α-D-erythro-pentofuranose-3-spiro-3'-(4'-amino-2'-N-methyl-5'-phenyl-5'H-2',3'-dihydroisothiazole-1',1'-dioxide) 
• 721924-42-1 1,2-O-isopropylidene-5-O-trityl-α-D-erythro-pentofuranose-3-spiro-3'-(4'-amino-2'-N-benzyl-5'H-2',3'-dihydroisothiazole-1',1'-dioxide) 
• 721924-30-7 3-amino-3-C-cyano-3-deoxy-1,2-O-isopropylidene-3-N-phenylmethanesulfonyl-5-O-trityl-α-D-ribofuranose 
• 721924-31-8 3-amino-3-N-benzyl-3-C-cyano-3-deoxy-1,2-O-isopropylidene-3-N-methanesulfonyl-5-O-trityl-α-D-ribofuranose 

Relevant articles and documents

Discovery of cytochrome bc1 complex inhibitors inspired by the natural product karrikinolide

The cytochrome bc1 complex (cyt bc1 or complex III) is a promising target of numerous antibiotics and fungicides. With an aim to indentify new lead structures for the bc1 complex, a series of novel inhibitors were discovered from the natural product karrikinolide for the first time. Extensive screening results suggested variable inhibitory activities of these compounds against succinate-cytochrome reductase [SCR, a mixture of respiratory complex II (SQR) and complex III (the bc1 complex)], implying the essential role of a 4-substituted phenyl group for the high potency. Exceptionally, compound 12g showed excellent inhibition potency having an IC50 value in the sub-micromolar range, demonstrating its higher potency than the commercial control amisulbrom by over two orders of magnitude. Further experiments inferred that these newly prepared compounds mainly target the bc1 complex. Seemingly, this work has presented a new lead scaffold for further development of bc1 complex inhibitors.

CYCLIC DI-NUCLEOTIDE COMPOUNDS AND METHODS OF USE

Disclosed are cyclic-di-nucleotide cGAMP analogs, methods of synthesizing the compounds, pharmaceutical compositions comprising the compounds thereof, and use of compounds and compositions in medical therapy.

Karrikins from plant smoke modulate bacterial quorum sensing

The discovery that plant smoke contains germination stimuli has led to the identification of a new class of signaling molecules named karrikins. Here we report a potential second role for these molecules: in various bacterial species-A. tumefaciens, P. aeruginosa and V. harveyi-they modulate bacterial quorum-sensing (QS), with very different outcomes. the Partner Organisations 2014.