24490-03-7

Usage

Uses

Used in Pharmaceutical Industry:
ETHYL 3-(TRIFLUOROMETHYL)CROTONATE is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of complex organic molecules that can be utilized in medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, ETHYL 3-(TRIFLUOROMETHYL)CROTONATE is employed as a reactive component in the creation of agrochemicals, leveraging its reactivity to produce compounds that can be used in crop protection and other agricultural applications.
Used in Flavor and Fragrance Industry:
ETHYL 3-(TRIFLUOROMETHYL)CROTONATE is used as a precursor in the synthesis of flavor and fragrance compounds, capitalizing on its fruity odor and chemical properties to create scents and tastes for various consumer products.
Used in Chemical Research and Development:
As a highly reactive compound, ETHYL 3-(TRIFLUOROMETHYL)CROTONATE is used in chemical research and development to explore new synthetic pathways and create novel organic molecules for a wide range of applications.

InChI:InChI=1/C7H9F3O2/c1-3-12-6(11)4-5(2)7(8,9)10/h4H,3H2,1-2H3/b5-4+

Upstream product

• 649-67-2 4,4,4-Trifluor-3-hydroxy-3-methyl-butansaeure-⁽¹⁾-ethylester 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 421-50-1 1,1,1-trifluoro-2-propanone 
• 338-03-4 4,4,4-trifluoro-3-hydroxy-3-methyl-butanoic acid 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 64-17-5 ethanol 
• 69056-67-3 3-methyl-4,4,4-trifluoro-2-butenoic acid 

Relevant academic research and scientific papers

1-Bromo-3-trifluoromethylbut-2-ene: synthesis and electrophilic reactivity

A three-step synthesis of 1-bromo-3-trifluoromethylbut-2-ene in 54percent overall yield is reported starting from 1,1,1-trifluoroacetone.The electrophilic reactivity of this compound towards various nucleophiles has been studied.Thus, for example, condensation with the sodium salt of diethyl malonate gave ethyl 2-carboethoxy-5-trifluoromethylhex-4-enoate in 66percent yield.

Synthesis of new β-trifluoromethyl containing GABA and β-fluoromethyl containing N-benzylpyrrolidinones

A whole series of 3-(mono-, di-, trifluoro)methyl-substituted N-benzylpyrrolidinones 5a-c was synthesized by deoxyfluorination of corresponding 3-functionalized N-benzylpyrrolidinones. New β-trifluoromethyl containing GABA 4a was obtained in two alternative ways: by successive hydrolysis and hydrogenolysis of 3-trifluoromethyl N-benzylpyrrolidinone 5a and from trifluoroacetone as starting compound.

Antiinflammatory activity of a series of substituted 2,3-dihydro-6-hydroxypyrimido[2,1-f]purine-4,8(1H,9H)-diones

A series of substituted analogues based on the novel 2,3-dihydro-6-hydroxypyrimido[2,1-f]purine-4,8(1H,9H)-dione ring system have been synthesized and shown to exhibit antiinflammatory activity in the adjuvant-induced arthritis rat model (AAR). The activi

Efforts in Synthesizing α,β-Unsaturated Trifluoromethyl-substituted Aldehydes

Hexafluoroacetone reacts with ethynylmagnesium bromide to yield (CF3)2C(OH)-CCH (1).Bromine can be added to the triple bond affording the cis/trans-isomer 2.With PCl5 1 yields the allene (CF3)2C=C=CClH (3).The addition of a metalated Schiff base to hexafluoroacetone leads to 4a which on hydrolysis yields (CF3)2C(OH)-CH2-CHO (4b).The reaction of (EtO)2P(O)CH2-R (R = CHO, CO2Et) with hexafluoroacetone gives α,β-unsaturated aldehydes or esters 6. 1,1,1-Trifluoroacetone provides analogous reactions.

Synthesis and Thermolysis of Highly Halogenated Δ1-Pyrazolines

The pyrolysis of highly halogenated Δ1-pyrazolines gives, in addition to cyclopropanes, rearranged olefins.