485-90-5

Basic information

• Product Name: 7-HYDROXY-8-METHOXYCOUMARIN
• Synonyms: Hydrangetin (7-OH, 8OMe);7-HYDROXY-8-METHOXYCOUMARIN;7-Hydroxy-8-methoxy-2H-1-benzopyran-2-one;8-Methoxyumbelliferone;Hydrangetin
• CAS NO: 485-90-5
• Molecular Formula: C₁₀H₈O₄
• Molecular Weight: 192.1681
• Mol File: 485-90-5.mol
• Article Data: 10

Chemical Properties

• Melting Point: 185 °C
• Boiling Point: 415.5°Cat760mmHg
• Flash Point: 173.3°C
• Appearance: /
• Density: 1.377
• Vapor Pressure: 1.7E-07mmHg at 25°C
• Refractive Index: 1.609
• PKA: 7.91±0.20(Predicted)
• CAS DataBase Reference: 7-HYDROXY-8-METHOXYCOUMARIN(CAS DataBase Reference)
• NIST Chemistry Reference: 7-HYDROXY-8-METHOXYCOUMARIN(485-90-5)
• EPA Substance Registry System: 7-HYDROXY-8-METHOXYCOUMARIN(485-90-5)

Safety Data

• Hazardous Substances Data: 485-90-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H8O4/c1-13-10-7(11)4-2-6-3-5-8(12)14-9(6)10/h2-5,11H,1H3

Upstream product

• 58922-29-5 2,4-dihydroxy-3-methoxybenzaldehyde 
• 108-24-7 acetic anhydride 
• 186581-53-3 diazomethane 
• 486-35-1 daphnetin 
• 486-55-5 daphnin 
• 29267-67-2 2-methoxyresorcinol 
• 623-47-2 propynoic acid ethyl ester 
• 87-66-1 2-hydroxyresorcinol 
• 74-88-4 methyl iodide 
• 2698-69-3 4-formyl-2-methoxy-3-nitrophenyl acetate 
• 881-68-5 vanillin acetate 
• 121-33-5 vanillin 
• 2450-26-2 2-nitrovanillin 
• 65535-50-4 7-Benzyloxy-8-hydroxycoumarin 

Downstream Products

• 483-92-1 luvangetin 
• 2445-80-9 7,8-dimethoxy-chromen-2-one 
• 882653-77-2 (Z)-3-(2,3,4-trimethoxyphenyl)acrylic acid 
• 116406-19-0 trans-2,3,4-trimethoxycinnamic acid 
• 484-13-9 Collinin 
• 1930-56-9 4-nitro-9-methoxy-7H-furo<3,2-g><1>benzopyran-7-one 
• 1930-54-7 4-bromo-9-methoxy-7H-furo[3,2-g]chromen-7-one 
• 110335-10-9 7-hydroxy-8-methoxy-6-(phenylhydrazono-methyl)-coumarin 
• 298-81-7 9-methoxy-7H-furo[3,2-g][1]benzopyran-7-one 
• 73155-42-7 Lacinartin 

Relevant articles and documents

SIMPLE COUMARINS FROM TWO POPULATIONS OF DIOSMA ACMAEOPHYLLA

Investigation of two collections of Diosma acmaeophylla afforded seven simple coumarins, three of which were common to both samples.The chemotaxonomic significance of the isolated coumarins is discussed. - Key Word Index: Diosma acmaeophylla; Rutaceae; 7-, 6,7- and 7,8-oxygenated coumarins; chemical systematics.

Chemically selective mono-methylation method of coumarin catechol compounds

The invention provides a chemically selective mono-methylation method of coumarin catechol compounds, and belongs to the field of natural drug synthesis. According to the method, catechol coumarin compounds are added into an organic reaction system in the presence of a proper amount of alkali catalyst, and high selectivity methylation reactions happen between the catechol coumarin compounds and a methylation reagent so as to obtain a mono-methylation product; wherein the mole ratio of the alkali to the catechol coumarin compounds is 1.0-5.0:1; the mole ratio of the methylation reagent to the catechol coumarin compounds is 1.0-2.0:1, the temperature of the reaction system is -20 to 10 DEG C, and the reaction time is 0.5 to 3 hours. The method has the characteristics of simple operation, mild conditions, good selectivity, and high yield, and can be used to prepare mono-methylation products of coumarin catechol compounds with different substituents.

New synthesis of hydrangettn and collinin

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