245057-86-7

Usage

Chemical structure

The compound has a prop-2-ene-1-one group attached to a 6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl group.

Synthetic compound

It is a synthetic compound, meaning it is created through chemical synthesis rather than being directly extracted from a natural source.

Potential pharmacological properties

The compound may have potential applications in the development of novel drugs or pharmaceutical products due to its unique structure and properties.

Biological and chemical properties

The specific biological or chemical properties of 1-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)prop-2-ene-1-one have not been fully elucidated, indicating that further research is needed to understand its potential uses and effects.

Organic synthesis

The compound may have potential applications in organic synthesis, which is the study of the formation and reactions of carbon-containing compounds.

Building block for other compounds

It may serve as a building block for the development of other chemical compounds, contributing to the creation of new materials or products.

Dimethoxy substitution

The presence of two methoxy groups (-OCH3) at the 6 and 7 positions of the isoquinoline ring may influence the compound's reactivity, stability, and potential applications.

Dihydroisoquinoline core

The dihydroisoquinoline core is a common structural motif found in various natural products and synthetic compounds with diverse biological activities.

Prop-2-ene-1-one functionality

The presence of a prop-2-ene-1-one group (an α,β-unsaturated ketone) in the molecule may contribute to its reactivity and potential use in chemical reactions and applications.

Upstream product

• 1745-07-9 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 814-68-6 acryloyl chloride 
• 2328-12-3 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline monohydrochloride 
• 3382-18-1 6,7-dimethoxy-3,4-dihydro-isoquinoline 
• 15486-96-1 3-Bromopropionyl chloride 

Downstream Products

• 1009104-85-1 SIS₃ 
• 1009104-85-1 ((E)-1-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one) 

Relevant academic research and scientific papers

AN ACTIVITY-GUIDE MAP OF ELECTROPHILE-CYSTEINE INTERACTIONS IN PRIMARY HUMAN IMMUNE CELLS

Disclosed herein are methods, pharmaceutical compositions, and vaccines for modulating an immune response. Also disclosed herein are methods, pharmaceutical compositions, and vaccines for inducing an immune response.

SMAD3 INHIBITORS

Smad3 inhibitor compounds, specifically a compound of Formula 1 or Formula 2, or a pharmaceutically acceptable salt thereof, and its use in treating or preventing cell proliferation or cancer in a subject are provided.

One-Pot Coupling-Cyclization-Alkylation Synthesis of 1,2,5-Trisubstituted 7-Azaindoles in a Consecutive Three-component Fashion

1,2,5-Trisubstituted 7-azaindoles are rapidly and efficiently prepared in a one-pot, copper-free alkynylation-cyclization-alkylation sequence starting from unprotected 2-aminopyridyl halides in a consecutive three-component fashion. By extension to a consecutive four-component coupling-cyclization-iodination-alkylation synthesis of 3-iodo-1-methyl-2-phenyl-1 H -pyrrolo[2,3- b ]pyridine, a concise synthesis of SIS3, a selective TGF-β1 and signaling inhibitor, was realized.

COMPOSITIONS AND METHODS OF MODULATING IMMUNE RESPONSE

Disclosed herein are methods, pharmaceutical compositions, and vaccines for modulating an immune response. Also disclosed, herein are methods, pharmaceutical compositions, and vaccines for inducing an immune response.

Synthesis, COX-1/2 inhibition activities and molecular docking study of isothiazolopyridine derivatives

One of the main challenges for nowadays medicine is drugs selectivity. In COX-1 and COX-2, the active sites are composed of the same group of amino acids with the exception of the only one residue in position 523, in COX-1 is an isoleucine, while in COX-2

Mechanistic studies on the catalytic asymmetric mannich-type reaction with dihydroisoquinolines and development of oxidative mannich-type reactions starting from tetrahydroisoquinolines

(Chemical Equation Presented) Detailed mechanistic studies on our recently reported asymmetric addition reactions of malonates to dihydroisoquinolines (DHIQs) catalyzed by chiral Pd(II) complexes were carried out. It was found that an N,O-acetal was gener

Synthesis and pharmacological evaluation of piperidinoalkanoyl-1,2,3,4- tetrahydroisoquinoline derivatives as novel specific bradycardic agents

A series of piperidinoalkanoyl-1,2,3,4-tetrahydroisoquinoline derivatives were synthesized, and their bradycardic activities were investigated in the isolated right atria of guinea pigs and in conscious rats. These efforts identified the achiral compound 2f, which exhibited potent and long-lasting bradycardic activity with minimal effects on mean blood pressure in conscious rats.