1009104-85-1

Basic information

• Product Name: Smad3 Inhibitor, SIS3
• Synonyms: Smad3 Inhibitor;Smad3 Inhibitor, SIS3;SIS3 free base
• CAS NO: 1009104-85-1
• Molecular Formula: C28H27N3O3
• Molecular Weight: 453.53228
• EINECS: -0
• Product Categories: Specific Inhibitor of Smad3, SIS3
• Mol File: 1009104-85-1.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Smad3 Inhibitor, SIS3(CAS DataBase Reference)
• NIST Chemistry Reference: Smad3 Inhibitor, SIS3(1009104-85-1)
• EPA Substance Registry System: Smad3 Inhibitor, SIS3(1009104-85-1)

Safety Data

• Hazardous Substances Data: 1009104-85-1(Hazardous Substances Data)

Usage

Uses

SMAD3 Inhibitor, SIS3 selectively inhibits TGF-β and activin. It has been shown to reduce TGF-β1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts.

Definition

ChEBI: An enamide resulting from the formal condensation of the amino group of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline with the carboxy group of (2E)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acrylic cid.

Upstream product

• 2328-12-3 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline monohydrochloride 
• 214342-66-2 3-iodo-N,N-dimethyl-pyridin-2-amine 
• 113975-22-7 2-fluoro-3-iodopyridine 
• 945608-15-1 3-iodo-1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridine 
• 245057-86-7 1-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)prop-2-ene-1-one 
• 1745-07-9 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 521984-95-2 1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde 
• 13534-99-1 2-Amino-3-bromopyridine 
• 536-74-3 phenylacetylene 
• 521984-94-1 1-methyl-2-phenyl-1H-pyrrolo-[2,3-b]pyridine 
• 116026-94-9 2--3-pyridinecarboxaldehyde 
• 945607-77-2 [3-(2,2-dichlorovinyl)-pyridin-2-yl]-methyl-amine 
• 945607-94-3 C₁₃H₁₆Cl₂N₂O₂ 
• 945607-75-0 [3-(2,2-dibromovinyl)-pyridin-2-yl]-methyl-amine 

Relevant articles and documents

Synthesis of 3-Halo-7-azaindoles through a 5- endo -dig Electrophilic Cyclization Reaction

Biologically useful 7-azaindoles were synthesized by electrophilic cyclization of 3-alkynyl- N, N -dimethylpyridine-2-amines with molecular iodine. By this simple atom-economical approach under ambient reaction conditions, a library of interesting 3-iodo-7-azaindoles were synthesized in high yields. To synthesize the corresponding 3-bromo- and 3-chloro-7-azaindoles, an environmentally benign copper-mediated cyclization was employed, with inexpensive, nontoxic, and noncorrosive sodium chloride and sodium bromide as the sources of chlorine and bromine, respectively.

Azaindole compound and application thereof

The invention provides an azaindole compound with a structure shown as a formula (I) and application of the azaindole compound. The azaindole compound can effectively inhibit SMAD3-phosphorylation andhas good anti-tumor activity in a rat LCC induced tumor model. Compared with a compound SIS3, part of the azaindole compound provided by the invention is obviously improved in water solubility. The azaindole compound provided by the invention is expected to become an effective drug for preventing and treating tumors.

2-SUBSTITUTED AZAIN DOLES AND 2 SUBSTITUTED THIENOPYRROLES, THEIR PRECURSORS AND NOVEL PROCESSES FOR THE PREPARATION THEREOF

The present invention relates generally to processes for the chemical synthesis of azaindole and thienopyrrole compounds, in particular azaindole and thienopyrrole compounds that are substituted at the 2-position of the azaindole or thienopyrrole ring, an