245124-53-2

Upstream product

• 71-43-2 benzene 
• 606-83-7 3,3-Diphenylpropionic acid 
• 140-10-3 (E)-3-phenylacrylic acid 
• 16618-72-7 3-phenyl-1-indanone 
• 93875-76-4 ethyl 1-phenyl-3-oxo-2,3-dihydro-1H-indene-2-carboxylate 

Relevant academic research and scientific papers

Synthesis of a novel class of non-peptide NK-2 receptor ligand, derived from 1-phenyl-3-pyrrol-1-ylindan-2-carboxamides

A series of trans,trans-1-phenyl-3-pyrrol-1-ylindan-2-carboxamide derivatives has been synthesized in eight steps starting from cinnamic acid or 3,3-diphenylpropionic acid. The trans,trans configuration of these carboxamides has been established by X-ray analysis and by NOE experiments in NMR. These new compounds were evaluated for their potential NK-1, NK-2 and NK-3 receptors binding affinity. The N,N-disubstituted carboxamides bound selectively on NK-2 receptors. Copyright

First synthesis of 1-phenyl-3-pyrrol-1-ylindan-2-carboxylic acid, a new scaffold of potential non-peptide endothelin receptor antagonists

The first synthesis of trans, trans-1-phenyl-3-pyrrol-1-ylindan-2- carboxylic acid, a key-intermediate in the access to new potential non- peptide endothelin receptor antagonists, is reported.