93875-76-4

Upstream product

• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 100-52-7 benzaldehyde 
• 16618-72-7 3-phenyl-1-indanone 
• 105-58-8 Diethyl carbonate 
• 140-10-3 (E)-3-phenylacrylic acid 
• 606-83-7 3,3-Diphenylpropionic acid 
• 71-43-2 benzene 
• 39626-31-8 ethyl 2-benzoyl-3-phenylacrylate 
• 94224-67-6 ethyl 1-oxo-3-phenyl-1H-indene-2-carboxylate 
• 94875-82-8 (3-oxo-1-phenyl-1,3-dihydro-isobenzofuran-1-yl)-malonic acid diethyl ester 

Downstream Products

• 245124-53-2 ethyl 3-amino-1-phenyl-1H-inden-2-carboxylate 
• 116598-03-9 (+/-)-benzoic acid-[10t(or c)-hydroxy-(4br,9ac)-4b,9,9a,10-tetrahydro-indeno[1,2-a]inden-9c(or t)-yl ester] 

Relevant academic research and scientific papers

Electronic tuning cyclization of aryl-1,4-enediones: AlCl3-mediated Nazarov-type cyclization to synthesize polysubstituted-1-indanones

An electronic tuning Nazarov-type cyclization protocol was proposed for the synthesis of polysubstituted-1-indanones from the readily available starting materials 1,4-enediones. AlCl3 was highlighted as the most efficient promoter for this reac

A systematic study on Knoevenagel reaction and Nazarov cyclization of less reactive carbonyl compounds using rare earth triflates and its applications

A systematic study of Knoevenagel reaction and Nazarov cyclization was made on variety of less reactive carbonyl compounds such as β-ketoesters, 1,3-diketones and cyclic active methylene compounds using Yb(OTf)3 as the catalyst. Recycling study confirms reusability of the catalyst without much loss of activity.

Synthesis of a novel class of non-peptide NK-2 receptor ligand, derived from 1-phenyl-3-pyrrol-1-ylindan-2-carboxamides

A series of trans,trans-1-phenyl-3-pyrrol-1-ylindan-2-carboxamide derivatives has been synthesized in eight steps starting from cinnamic acid or 3,3-diphenylpropionic acid. The trans,trans configuration of these carboxamides has been established by X-ray analysis and by NOE experiments in NMR. These new compounds were evaluated for their potential NK-1, NK-2 and NK-3 receptors binding affinity. The N,N-disubstituted carboxamides bound selectively on NK-2 receptors. Copyright

First synthesis of 1-phenyl-3-pyrrol-1-ylindan-2-carboxylic acid, a new scaffold of potential non-peptide endothelin receptor antagonists

The first synthesis of trans, trans-1-phenyl-3-pyrrol-1-ylindan-2- carboxylic acid, a key-intermediate in the access to new potential non- peptide endothelin receptor antagonists, is reported.

Selective synthesis of 1-indanones via tandem Knoevenagel condensation-cycloalkylation of β-dicarbonyl compounds and aldehydes

Aromatic 1,3-dicarbonyl compounds react with not enolizable aldehydes in the presence of C2H5MgBr or AlCl3 affording 2-carbethoxy- and 2-acetyl-1-indanones via tandem, Knoevenagel condensation-cycloalkylation process.

Friedel-Crafts Coordinated Processes: 1-Oxoindanes from Aromatic β-Dicarbonyl Compounds and Aldehydes

Variously substituted 1-oxoindanes were synthesized by highly selective bis-alkylation of aromatic β-dicarbonyl compounds with non enolizable aldehydes. - Key words: 1-Oxoindanes; β-dicarbonyl chelates; vicinal bis-alkylation.