24522-15-4Relevant academic research and scientific papers
Highly efficient chemoselective construction of 2,2-dimethyl-6-substituted 4-piperidones via multi-component tandem Mannich reaction in ionic liquids
Feng, Li-Chun,Sun, Ya-Wei,Tang, Wei-Jun,Xu, Li-Jin,Lam, Kim-Lung,Zhou, Zhongyuan,Chan, Albert S. C.
supporting information; experimental part, p. 949 - 952 (2010/08/20)
The room temperature ionic liquid [bmim][PF6] has been demonstrated to be an efficient and recyclable medium for highly chemoselective synthesis of 2,2-dimethyl-6-substituted 4-piperidones via a l-proline catalyzed tandem Mannich reaction of ammonia, aldehydes and acetone, and good yields were achieved for aryl and alkyl aldehydes.
Direct aldol and tandem Mannich reactions in room temperature ammonia solutions
Feng, Lichun,Xu, Lijin,Lam, Kimhung,Zhou, Zhongyuan,Yip,Chan, Albert S.C.
, p. 8685 - 8689 (2007/10/03)
An economical, simple, and efficient direct aldol reaction via the double activation of both aldehydes and ketones by ammonia has been developed. An unprecedented tandem Mannich reaction was observed when hydroxybenzaldehydes, pyrrole-2-carboxyaldehyde, a
Intramolecular Mannich reaction in the asymmetric synthesis of polysubstituted piperidines: concise synthesis of the dendrobate alkaloid (+)-241D and its C-4 epimer.
Davis,Chao,Rao
, p. 3169 - 3171 (2007/10/03)
[reaction: see text] The intramolecular Mannich reaction of delta-amino beta-keto esters with aldehydes and ketones is a new methodology for the synthesis of polysubstituted piperidines and is illustrated by the concise asymmetric synthesis of the dendrob
