245359-77-7

Upstream product

• 245359-84-6 (2-benzyl-benzo[b]thiophen-3-yl)-(4-methoxy-phenyl)-methanone 
• 100-07-2 4-methoxy-benzoyl chloride 
• 250268-35-0 (2-benzyl-benzo[b]thiophen-3-yl)-(4-hydroxy-phenyl)-methanone 
• 3407-15-6 2-benzyl-benzo[b]thiophene 

Relevant academic research and scientific papers

Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia

This invention provides compounds of Formula I having the structure wherein: A, B, R1, R2, R3, R4, R5, and R6 are as defined in the specification, or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.

PTP1B inhibition and antihyperglycemic activity in the ob/ob mouse model of novel 11-arylbenzo[b]naphtho[2,3-d]furans and 11-arylbenzo[b]naphtho[2,3- d]thiophenes

We have reported on a series of novel, potent, and selective PTPase inhibitors that function as oral antidiabetic agents. Compounds 6 and 7 are particularly notable in this regard. They were both low nanomolar inhibitors and lowered glucose in the diabeti