3407-15-6

Basic information

• Product Name: Benzo[b]thiophene, 2-(phenylmethyl)-
• CAS NO: 3407-15-6
• Molecular Formula: C15H12S
• Molecular Weight: 224.326
• Mol File: 3407-15-6.mol
• Article Data: 22

Chemical Properties

• CAS DataBase Reference: Benzo[b]thiophene, 2-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzo[b]thiophene, 2-(phenylmethyl)-(3407-15-6)
• EPA Substance Registry System: Benzo[b]thiophene, 2-(phenylmethyl)-(3407-15-6)

Safety Data

• Hazardous Substances Data: 3407-15-6(Hazardous Substances Data)

Upstream product

• 100-44-7 benzyl chloride 
• 95-15-8 Benzo[b]thiophene 
• 100-39-0 benzyl bromide 
• 3262-89-3 triphenylboroxine 
• 17890-56-1 benzothiophene-2-methanol 
• 100-52-7 benzaldehyde 
• 26260-02-6 2-iodobenzaldehyde 
• 6630-33-7 ortho-bromobenzaldehyde 
• 98-86-2 acetophenone 
• 98437-23-1 benzo[b]thiophene-2-boronic acid 
• 6314-28-9 benzo[b]thiophene-2-carboxylic acid 
• 4688-18-0 benzo[b]thiophen-2-ylmethyl acetate 
• 98-80-6 phenylboronic acid 
• 62167-00-4 DL-2-phenylthioacetic acid 

Downstream Products

• 250351-64-5 (2-benzyl-benzo[b]thiophen-3-yl)-(3-methoxy-phenyl)-methanone 
• 250351-65-6 (2-benzyl-benzo[b]thiophen-3-yl)-(3,4-dimethoxy-phenyl)-methanone 
• 1398124-09-8 2-benzyl-2,3-dihydrobenzo[b]thiophene 

Relevant articles and documents

Synthesis of Indole/Benzofuran-Containing Diarylmethanes through Palladium-Catalyzed Reaction of Indolylmethyl or Benzofuranylmethyl Acetates with Boronic Acids

The palladium-catalyzed synthesis of indole/benzofurancontaining diarylmethanes starting from indolylmethyl or benzofuranylmethyl acetates with boronic acids has been investigated. The success of the reaction is influenced by the choice of precatalyst: with indolylmethyl acetates the reaction works well with [Pd(η3-C3H5)Cl]2/XPhos while with benzofuranylmethyl acetates Pd2(dba)3/XPhos is more efficient. The good to high yields and the simplicity of the experimental procedure make this protocol a versatile synthetic tool for the preparation of 2- and 3-substituted indoles and 2-benzo[b]furans. The methodology can be advantageously extended to the preparation of a key precursor of Zafirlukast.

Dearomative Dienolate-Mediated Catalysis: A Remote Activation Strategy for Asymmetric Functionalization of Benzylic C-H Bonds of Heteroaryl Aldehydes

A dearomative remote activation strategy for the asymmetric functionalization of benzylic C-H bonds of heteroaryl aldehydes under bifunctional Br?nsted base catalysis has been developed. The in situ generated o-QDMs-type dienolate intermediates were effic

A Zwitterionic Palladium(II) Complex as a Precatalyst for Neat-Water-Mediated Cross-Coupling Reactions of Heteroaryl, Benzyl, and Aryl Acid Chlorides with Organoboron Reagents

The Suzuki–Miyaura cross-coupling (SMC) reactions of several heteroaryl chlorides, benzyl chlorides, and aryl acid chlorides with (hetero)arylboron reagents have been investigated in the presence of [Pd(HL1)(PPh3)Cl2] (I) [HL1 = 3-[(2,6-diisopropylphenyl)-1-imidazolio]-2-quinoxalinide] as catalyst and K2CO3 as base in neat water. The synthesis of the heterocycle-containing biaryls required the addition of 2 mol-% of a phosphine ligand (PPh3 or X-Phos). A combination of more than 115 substrates were screened and it was found that I is a versatile catalyst that can produce heterocycle-containing biaryls, diarylmethanes, and benzophenones in moderate-to-excellent yields.