245364-67-4

Upstream product

• 349-88-2 4-Fluorobenzenesulfonyl chloride 
• 15100-75-1 L-phenylalanine tert-butyl ester hydrochloride 
• 63-91-2 L-phenylalanine 

Downstream Products

• 245364-96-9 2-[(4-fluoro-benzenesulfonyl)-(4-methyl-benzyl)-amino]-3-phenyl-propionic acid tert-butyl ester 
• 245364-93-6 2-[(4-chloro-benzyl)-(4-fluoro-benzenesulfonyl)-amino]-3-phenyl-propionic acid tert-butyl ester 
• 97801-53-1 (S)-2-(4-fluorophenylsulfonamido)-3-phenylpropanoic acid 
• 245365-23-5 N-benzyloxy-2-[(4-fluoro-benzenesulfonyl)-(4-methyl-benzyl)-amino]-3-phenyl-propionamide 
• 245365-20-2 N-benzyloxy-2-[(4-chloro-benzyl)-(4-fluoro-benzenesulfonyl)-amino]-3-phenyl-propionamide 
• 245365-17-7 2-[benzyl-(4-fluoro-benzenesulfonyl)-amino]-N-benzyloxy-3-phenyl-propionamide 
• 245364-90-3 2-[benzyl-(4-fluoro-benzenesulfonyl)-amino]-3-phenyl-propionic acid tert-butyl ester 

Relevant academic research and scientific papers

Small-molecule inhibitors of the TLR3/dsRNA complex

The protein-RNA interface has been regarded as "undruggable" despite its importance in many biological processes. The toll-like receptor 3 (TLR3)/double-stranded RNA (dsRNA) complex provides an exciting target for a number of infectious diseases and cancers. We describe the development of a series of small-molecule probes that were shown to be competitive inhibitors of dsRNA binding to TLR3 with high affinity and specificity. In a multitude of assays, compound 4a was profiled as a potent antagonist to TLR3 signaling and also repressed the expression of downstream signaling pathways mediated by the TLR3/dsRNA complex, including TNF-α and IL-1β.

Synthesis of an array of potential matrix metalloproteinase inhibitors using a sequence of polymer-supported reagents

Polymer-supported reagents and sequestering agents may be used to generate an array of variously substituted hydroxamic acid derivatives as potential inhibitors of matrix metalloproteinases without any chromatographic purification step.