24541-44-4

Basic information

• Product Name: Phenol, 2-azido-
• CAS NO: 24541-44-4
• Molecular Formula: C6H5N3O
• Molecular Weight: 135.125
• Mol File: 24541-44-4.mol
• Article Data: 47

Chemical Properties

• CAS DataBase Reference: Phenol, 2-azido-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 2-azido-(24541-44-4)
• EPA Substance Registry System: Phenol, 2-azido-(24541-44-4)

Safety Data

• Hazardous Substances Data: 24541-44-4(Hazardous Substances Data)

Upstream product

• 95-56-7 2-hydroxybromobenzene 
• 533-58-4 2-Iodophenol 
• 89466-08-0 2-hydroxyphenyl boronic acid 
• 95-55-6 2-amino-phenol 

Downstream Products

• 33345-15-2 Ortho-(P,P,P-Triphenyl-phosphinimido)-phenol 
• 78479-87-5 1-Azido-2-<(1-cyclopentenyl)methoxy>benzene 
• 78479-88-6 1-Azido-2-<(1-cyclohexenyl)methoxy>benzene 
• 4377-76-8 6-Imino-2,4-cyclohexadien-1-one 
• 1352170-79-6 C₂₆H₂₂N₈O₄ 
• 59-49-4 2-Benzoxazolinone 
• 55000-07-2 o-(prop-2-enyloxy)phenyl azide 
• 1206797-33-2 ((2-azidophenoxy)methyl)benzene 
• 33354-52-8 N-(o-Hydroxyphenyl)-P,P,P-Triphenylphosphin-imidium-jodid 
• 833-50-1 2-phenylbenzo[d]oxazole 
• 93638-65-4 2-phenyl diphenylphosphinate 
• 80750-60-3 2-(diphenylmethyleneamino)phenyl diphenylphosphinate 
• 80750-59-0 2-(3-methyl-3-phenyl-1,3-diazapropenyl)phenyl diphenylphosphinate 

Relevant articles and documents

Synthesis and characterization of 1,2,3-triazoles-linked urea hybrid sensor for selective sensing of fluoride ion

Two urea-linked 1,2,3-triazole based sensors (5a and 5b) have been synthesized by 1,3-dipolar cycloaddition between 1-(4-fluorophenyl)-3-(prop-2-yn-1-yl)urea (2) and phenyl azides (4a-4b) via copper(I)-catalyzed click reaction. The synthesized sensors 5a

Synthesis, antiproliferative, docking and DFT studies of benzimidazole derivatives as EGFR inhibitors

In the present work, new benzimidazole linked 1,2,3-triazole hybrids have been synthesized and screened for antiproliferative and EGFR kinase inhibitory activities.The structures of these hybrids were elucidated using IR, NMR, mass spectrometry and elemen

2-((1-Phenyl-1H-1,2,3-triazol-4-yl)methyl)-2-azabicyclo[3.2.1]octan-3-one derivatives: Simplification and modification of aconitine scaffold for the discovery of novel anticancer agents

The molecular chaperone heat shock protein 90 (Hsp90) is a promising target for cancer therapy. Natural product aconitine is a potential Hsp90 inhibitor reported in our previous work. In this study, we designed and synthesized a series of 2-((1-phenyl-1H-1,2,3-triazol-4-yl)methyl)-2-azabicyclo[3.2.1]octan-3-one derivatives as potent Hsp90 inhibitors by simplifying and modifying aconitine scaffold. Among these compounds, 14t exhibited an excellent antiproliferative activity against LoVo cells with an IC50 value of 0.02 μM and a significant Hsp90α inhibitory activity with an IC50 value of 0.71 nM. Molecular docking studies provided a rational binding model of 14t in complex with Hsp90α. The following cell cycle and apoptosis assays revealed that compound 14t could arrest cell cycle at G1/S phase and induce cell apoptosis via up-regulation of bax and cleaved-caspase 3 protein expressions while inhibiting the expressions of bcl-2. Moreover, 14t could inhibit cell migration in LoVo and SW620 cell lines. Consistent with in vitro results, 14t significantly repressed tumor growth in the SW620 xenograft mouse model.