24542-55-0

Basic information

• Product Name: [(2,6-Dichloro-phenyl)-phenyl-amino]-oxo-acetyl chloride
• Synonyms: [(2,6-Dichloro-phenyl)-phenyl-amino]-oxo-acetyl chloride
• CAS NO: 24542-55-0
• Molecular Weight: 328.582
• Mol File: 24542-55-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [(2,6-Dichloro-phenyl)-phenyl-amino]-oxo-acetyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: [(2,6-Dichloro-phenyl)-phenyl-amino]-oxo-acetyl chloride(24542-55-0)
• EPA Substance Registry System: [(2,6-Dichloro-phenyl)-phenyl-amino]-oxo-acetyl chloride(24542-55-0)

Safety Data

• Hazardous Substances Data: 24542-55-0(Hazardous Substances Data)

Upstream product

• 79-37-8 oxalyl dichloride 
• 15307-93-4 N-phenyl-2,6-dichloroaniline 

Downstream Products

• 24542-74-3 1-(2,6-Dichlorphenyl)-2,3-indoldion 
• 15307-79-6 diclofenac sodium 
• 66156-75-0 2-(2-((2,6-dichlorophenyl)amino)phenyl)-2-oxoacetic acid 

Relevant articles and documents

Synthesis and quantitative structure-activity relationships of diclofenac analogues

The synthesis of a series of 2-anilinophenylacetic acid, close analogues of diclofenac, is described. These compounds were tested in two models used for evaluating the activity of nonsteroidal antiinflammatory drugs (NSAID's), inhibition of cyclooxygenase enzyme activity in vitro, and adjuvant-induced arthritis (AdA) in rats. Statistically significant correlations were found between the inhibitory activities of the compounds in these two models, indicating that cyclooxygenase inhibition seems to be the underlying mechanism for the antiinflammatory activity of these compounds. Quantitative structure-activity relationship (QSAR) analysis revealed that the crucial parameters for activity in both models were the lipophilicity and the angle of twist between the two phenyl rings. Optimal activities were associated with halogen or alkyl substituents in both ortho positions of the anilino ring. Compounds with OH groups in addition to two ortho substituents or compounds with only one or no ortho substituents were less active.