66156-75-0

Basic information

• Product Name: 2-(2,6-Dichloroanilino)-Phenylglyoxylic acid
• Synonyms: 2-(2,6-Dichloroanilino)-Phenylglyoxylic acid
• CAS NO: 66156-75-0
• Molecular Formula: C14H9Cl2NO3
• Molecular Weight: 310.136
• Mol File: 66156-75-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(2,6-Dichloroanilino)-Phenylglyoxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,6-Dichloroanilino)-Phenylglyoxylic acid(66156-75-0)
• EPA Substance Registry System: 2-(2,6-Dichloroanilino)-Phenylglyoxylic acid(66156-75-0)

Safety Data

• Hazardous Substances Data: 66156-75-0(Hazardous Substances Data)

Usage

General Description

2-(2,6-Dichloroanilino)-Phenylglyoxylic acid is a chemical compound that is often used as a reagent in organic chemistry. It is a derivative of phenylglyoxylic acid, with the addition of 2,6-dichloroanilino group. 2-(2,6-Dichloroanilino)-Phenylglyoxylic acid has a variety of applications, including as a building block for the synthesis of pharmaceuticals and other organic compounds. Its structure and properties make it useful in the development of new drug molecules and in the study of organic chemical reactions. The compound is also known for its potential as a fluorescent labeling reagent in biological and chemical research applications.

Upstream product

• 24542-74-3 1-(2,6-Dichlorphenyl)-2,3-indoldion 
• 15307-93-4 N-phenyl-2,6-dichloroaniline 
• 24542-55-0 [(2,6-Dichloro-phenyl)-phenyl-amino]-oxo-acetyl chloride 
• 89796-99-6 aceclofenac 

Downstream Products

• 15307-79-6 diclofenac sodium 
• 66867-42-3 ethyl 2-(2,6-dichloroanilino)phenylglyoxylate 
• 66867-41-2 ethyl 2-(2,6-dichloroanilino)phenylglycolate 
• 66867-40-1 methyl 2-(2,6-dichloroanilino)phenylglycolate 
• 69591-18-0 2-(2,6-dichloroanilino)phenylglycolic acid 
• 66156-76-1 methyl 2-(2,6-dichloroanilino)phenylglyoxylate 

Relevant articles and documents

Isolation and structural characterization of degradation products of aceclofenac by HPLC, HRMS and 2D NMR

The stability of aceclofenac under stress conditions was assessed to identify the degradation products. So, it was subjected to stress conditions like acid, base and oxidation, according to ICH guideline Q1A (R2). One degradation product formed when the drug was subjected to acid stress. Three degradation products were formed during the basic stress condition. The drug substance was found to be stable to oxidative stress. The degradants formed during the stress were separated on a C-18 column using gradient preparative HPLC elution. The only product (DP-2) formed during the acid stress and this one is same as of one of the three degradation products (DP-1, DP-2, DP-3) were formed during base stress. 1D and 2D NMR spectra and mass spectral analysis supported the proposed structures for the products. The products DP-2 and DP-3 have been reported earlier but this is the first report of product DP-1 as a degradation product of aceclofenac.

Substituted phenylglycolic acid and its pharmaceutically acceptable esters and salts, and processes for preparing the same

Novel substituted phenylglycolic acid represented by the formula STR1 AND ITS PHARMACEUTICALLY ACCEPTABLE NON-TOXIC ESTERS AND SALTS HAVE POTENT ANALGESIC, ANTI-INFLAMMATORY AND ANTIPYRETIC ACTIVITIES, A LOW TOXICITY AND A SATISFACTORY THERAPEUTIC INDEX, AND CAN BE FAVORABLY EMPLOYED AS A MEDICINE FOR TREATMENT OF VARIOUS INFLAMMATORY DISEASES SUCH AS ARTHRITIS, COMMON COLD, RHEUMATISM AND LIKE INFLAMMATIONS AND ALSO FOR ANALGESIC AND ANTIPYRETIC PURPOSES. The substituted phenylglycolic acid is prepared by reacting a lower alkyl ester of 2-(2,6-dichloroanilino)phenylglycolic acid with a basic substance, which lower alkyl ester is also a novel compound and can be obtained starting from 1-(2,6-dichlorophenyl)indole-2,3-dione through 2-(2,6-dichloroanilino)phenylglyoxylic acid and, in turn, a lower alkyl ester of 2-(2,6-dichloroanilino)-phenylglyoxylic acid.