245487-40-5

Usage

Chemical compound

1-cyclohexylpiperazine hydrochloride is a chemical compound commonly used in pharmaceutical research and drug development.

Derivative of piperazine

It is a derivative of piperazine, which gives it its unique chemical properties.

Interaction with receptors

1-cyclohexylpiperazine hydrochloride has the ability to interact with various receptors in the body, making it useful as a precursor in the creation of new pharmaceutical drugs.

Hydrochloride form

The compound is in hydrochloride form, which enhances its solubility and stability, making it more suitable for use in pharmaceutical applications.

Potential medical uses

1-cyclohexylpiperazine hydrochloride has been studied for its potential use in the treatment of various medical conditions, including neurological disorders and psychiatric illnesses.

Upstream product

• 108-85-0 1-bromocyclohexane 
• 1224935-95-8 4-cyclohexyl-piperazine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 17766-28-8 cyclohexylpiperazine 

Relevant academic research and scientific papers

Preparation method of 1-cyclohexylpiperazine

The invention discloses a preparation method of 1-cyclohexylpiperazine. The method comprises the steps of carrying out reflux reaction on cyclohexyl halide, 1-Boc-piperazine and inorganic base in an organic solvent, filtering after the reaction is finished, and concentrating to obtain an intermediate 1; removing Boc from the intermediate 1 under an acidic condition, drying by distillation after the reaction is finished, pulping with isopropanol, and filtering to obtain solid 1-cyclohexyl piperazine hydrochloride; dissolving with water, adding an inorganic base to adjust the pH value to 12 to 14, extracting with an extraction solvent, drying the solvent by distillation to obtain a crude product of 1-cyclohexylpiperazine, and carrying out reduced pressure distillation on the crude product through an oil pump to obtain a pure product of 1-cyclohexylpiperazine. In the synthesis process of the intermediate 1, use of sodium triacetoxyborohydride and sodium hydroxide is avoided, the production cost is greatly saved, meanwhile, only filtering is needed for aftertreatment, the method is very simple, and time and labor are saved.

PIPERAZINYL AND DIAZAPANYL BENZAMIDES AND BENZTHIOAMIDES

Substituted piperazinyl and diazepanyl benzamides and benzthioamides of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.