24550-58-1Relevant academic research and scientific papers
Design, synthesis and evaluation of substituted phenylpropanoic acid derivatives as peroxisome proliferator-activated receptor (PPAR) activators: Novel human PPARα-selective activators
Miyachi, Hiroyuki,Nomura, Masahiro,Tanase, Takahiro,Takahashi, Yukie,Ide, Tomohiro,Tsunoda, Masaki,Murakami, Koji,Awano, Katsuya
, p. 77 - 80 (2007/10/03)
A series of substituted phenylpropanoic acid derivatives was prepared as part of a search for subtype-selective human peroxisome proliferator-activated receptor (PPAR) activators. Structure-activity relationship studies indicated that the substituent at the α-position of the carboxyl group plays a key role in determining the potency and the selectivity for PPAR transactivation.
