24555-55-3Relevant academic research and scientific papers
Structure activity relationships of 4-hydroxy-2-pyridones: A novel class of antituberculosis agents
Ng, Pearly Shuyi,Manjunatha, Ujjini H.,Rao, Srinivasa P.S.,Camacho, Luis R.,Ma, Ngai Ling,Herve, Maxime,Noble, Christian G.,Goh, Anne,Peukert, Stefan,Diagana, Thierry T.,Smith, Paul W.,Kondreddi, Ravinder Reddy
, p. 144 - 156 (2015/11/16)
Pyridone 1 was identified from a high-throughput cell-based phenotypic screen against Mycobacterium tuberculosis (Mtb) including multi-drug resistant tuberculosis (MDR-TB) as a novel anti-TB agent and subsequently optimized series using cell-based Mtb ass
Anti-mycobacterial 4-hydroxy-3-phenylpyridin-2(1H)-ones
Dannhardt, G,Meindl, W,Schober, B D,Kappe, T
, p. 599 - 604 (2007/10/02)
4-Hydroxy-3-phenylpyridin-2 (1H)-ones with different substituents either at N-1 or in the phenyl group were synthesized by reaction of ethyl β-aminocrotonates with dialkyl malonates or 'magic malonates' (2,4,6-trichlorophenyl malonates).The evaluation of these compounds on Mycobacterium tuberculosis H37Ra, Escherichia coli B and Staphylococcus aureus ATCC 25923 showed significant inhibitory effects on M tuberculosis (5g and 5s, MIC=8μg/ml).A structure-activity relationship is discussed.
